The Association between Maternal Parity and Birth Defects
The Association between Maternal Parity and Birth Defects
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DOI：
10.1002/bdra.23360
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发表时间：
2015-02-01
影响因子：
--
通讯作者：
Waller, Dorothy Kim
中科院分区：
文献类型：
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作者：
McNeese, Melanie L.;Selwyn, Beatrice Josephine;Waller, Dorothy Kim
背景以前的研究观察到，第一胎与某些类别的出生缺陷的风险增加有关。然而，进行了多项统计测试，尚不清楚这些关联中的哪一种将在更大的研究中重复。我们使用了一个大型数据库来评估产妇产次与65种出生缺陷(包括以前没有研究过的出生缺陷)之间的关系。方法利用德克萨斯州出生缺陷登记处1999-2009年的数据，将第一胎、第三胎、第四胎或更高出生时发生出生缺陷的风险与第二次出生时发生出生缺陷的风险进行比较。结果第一次生育的女性与第二次生育的女性相比，65种出生缺陷中有24种的婴儿出生几率显著增加。我们还观察到第一次生育与五种以前没有报道过的出生缺陷风险的增加之间的关系(小阴茎、轴前多指、胸椎畸形、腰椎畸形和骶骨畸形)。与第二胎相比，第三胎、第四胎或更高出生的女性生下65个出生缺陷中的5个的几率显著增加。结论我们对与第一胎相关的出生缺陷类别的观察与之前两项研究的观察结果高度一致。需要对可能增加第一胎中特定出生缺陷风险的生物、行为和环境因素进行研究，以进一步探索这些联系。出生缺陷研究(A部分)103：144-156,2015(C)2015 Wiley期刊，Inc.
BACKGROUNDPrevious studies observed that first birth is associated with an increased risk of some categories of birth defects. However, multiple statistical tests were conducted and it was unclear which of these associations would be replicated in a larger study. We used a large database to assess the association between maternal parity and 65 birth defects including birth defects that have not been previously studied.METHODSUsing data from the Texas Birth Defects Registry for years 1999-2009, the risk of a birth defect occurring in a first, third, or fourth or higher birth was compared to the risk of a birth defect occurring in a second birth.RESULTSWomen having their first birth had significantly increased odds of having an infant with 24 of 65 categories of birth defects when compared to women having their second birth. We also observed associations between first birth and an increased risk of five birth defects not previously reported (small penis, preaxial polydactyly, anomalies of the thoracic vertebrae, anomalies of the lumbar vertebrae, and sacroccygeal anomalies). Women having their third or fourth or higher birth had significantly increased odds of giving birth to infants with five of 65 birth defects when compared to second births.CONCLUSIONSOur observations regarding the categories of birth defects that were associated with first births were highly consistent with observations from two previous studies. Research into biological, behavioral, and environmental factors that may increase the risk of specific birth defects among first births is needed to further explore these associations. Birth Defects Research (Part A) 103:144-156, 2015 (c) 2015 Wiley Periodicals, Inc.