Adiponectin Is a Negative Regulator of Bone Mineral and Bone Strength in Growing Mice
Adiponectin Is a Negative Regulator of Bone Mineral and Bone Strength in Growing Mice
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DOI：
10.3181/0806-rm-192
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发表时间：
2008-12-01
影响因子：
3.2
通讯作者：
Ward, Wendy E.
中科院分区：
文献类型：
--
作者：
Ealey, Kafi N.;Kaludjerovic, Jovana;Ward, Wendy E.
肥胖与骨矿物质密度（BMD）增加有关，但其机制尚不清楚。血清脂肪因子脂联素水平与肥胖呈负相关，但其与骨量关系的研究结果相互矛盾。本研究的目的是比较8周龄和16周龄脂联素转基因小鼠（AdTg）股骨和腰椎的骨矿物质含量（BMC）、BMD和生物力学性能。这些小鼠表现出显著升高的循环脂联素，但与用作对照的野生型（WT）同窝小鼠相比具有相似的体重。与对照组相比，雌性AdTg小鼠在8周龄和16周龄时显示出显著较低的股骨BMC，并且两种性别的8周龄AdTg小鼠的股骨颈峰值负荷显著较低。与WT相比，雌性AdTg小鼠在8周龄时个体腰椎压缩测试的峰值载荷显著较低，并且这种差异在16周龄时持续存在。此外，16周龄雄性AdTg小鼠的腰椎BMC显著低于WT，尽管椎骨峰值负荷没有差异。血清脂联素水平与股骨BMC呈负相关。总之，升高的循环脂联素抑制生长小鼠骨量的获得，并导致功能强度的生物力学指标降低，而功能强度是骨折易感性的替代指标。这些结果支持循环脂联素作为代谢环节的作用，至少可以部分解释肥胖与骨量和骨折易感性降低之间的正相关关系。Exp Biol Med 233：1546-1553。2008
Obesity is associated with increased bone mineral density (BMD) but the mechanism for this is unclear. Serum levels of the adipokine adiponectin are inversely correlated with obesity, but results from studies on its relationship to bone mass are conflicting. The objective of this study was to compare bone mineral content (BMC), BMD and biomechanical strength properties of femur and lumbar vertebrae in 8- and 16-week old adiponectin transgenic mice (AdTg). These mice exhibit significantly elevated circulating adiponectin but have similar body weights compared to wild-type (WT) littermates that were used as controls. Female AdTg mice displayed significantly lower femur BMC at 8 and 16 weeks of age and femur neck peak load was significantly lower in 8-week old AdTg mice of both genders compared to controls. The peak load from compression testing of an individual lumbar vertebra was significantly lower in female AdTg mice compared to WT at 8 weeks, and this difference persisted at 16 weeks of age. In addition, lumbar vertebrae BMC was significantly lower in 16-week old male AdTg mice compared to WT although vertebra peak load was not different. Serum adiponectin levels were inversely correlated with femur BMC. In summary, elevated circulating adiponectin inhibits the acquisition of bone mass in growing mice and results in decreased biomechanical measures of functional strength that are surrogate measures of susceptibility to fractures. These results support a role for circulating adiponectin as a metabolic link that can explain, at least in part, the positive relationship between obesity and both bone mass and reduced susceptibility to fractures. Exp Biol Med 233:1546-1553. 2008