Quantitative assessment of injury in rat spinal cords in vivo by MRI of water diffusion tensor
Quantitative assessment of injury in rat spinal cords in vivo by MRI of water diffusion tensor
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DOI：
10.1007/s00723-008-0095-7
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发表时间：
2008-07-01
影响因子：
1
通讯作者：
Adamek, D.
中科院分区：
文献类型：
--
作者：
Krzyzak, A. T.;Jasinski, A.;Adamek, D.
本文报告了大鼠脊髓损伤后6h内的磁共振扩散张量成像（DTI）。将DTI结果与组织病理学结果进行比较。这项工作的目的是将大鼠脊髓损伤的存在与表观扩散张量分量的统计学显著变化相关联，以找到在损伤的可视化中有用的参数。表观扩散张量加权数据测量在体内创伤性损伤后1小时，由健康和受伤的大鼠脊髓上的定义的十几个感兴趣的区域的控制重量下降。在灰质和白色质的损伤区域检测到显著的改变。灰质的差异可以解释的基础上，由于缺血细胞毒性水肿，并证实了神经元的组织学观察。扩散属性中的白色物质变化与机械植入物对神经微观结构的破坏相关。
Magnetic resonance diffusion tensor imaging (DTI) of control and injured spinal cord of rats in vivo during first 6 h after the trauma was reported. DTI and histopathological results were compared. The aim of this work was to correlate the presence of damage of rat spinal cord with statistically significant changes in the apparent diffusion tensor components, in order to find the parameters that are useful in the visualization of the injury. Apparent diffusion tensor weighted data were measured in vivo 1 h after traumatic injury induced by a controlled weight drop on healthy and injured rat spinal cords for defined dozen regions of interest. Significant alternations in the injured regions of gray matter and white matter were detected. The differences in gray matter can be explained on the basis of cytotoxic edema due to ischemia and they are confirmed by the histological observations of neurons. The white matter changes in diffusional attributes are associated with the destruction of the nerve microstructure by the mechanical implant.