The origin of osteoclasts: An immunohistochemical study on macrophages and osteoclasts in embryonic rat bone
The origin of osteoclasts: An immunohistochemical study on macrophages and osteoclasts in embryonic rat bone
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破骨细胞的起源：大鼠胚胎骨中巨噬细胞和破骨细胞的免疫组织化学研究
DOI：
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发表时间：
1986
影响因子：
4.2
通讯作者：
C. Dijkstra
中科院分区：
文献类型：
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作者：
T. Sminia;C. Dijkstra
用一组能识别单核细胞和巨噬细胞的单抗(ED1、ED2和ED3)研究了胚胎大鼠骨原基中破骨细胞的起源。ED1识别单核细胞和巨噬细胞。在发育骨软骨膜/骨膜中可见ED1阳性的单核吞噬细胞。当软骨变得肥大时，这些细胞开始渗入原基。在骨形成过程中，在发育中的骨髓腔和靠近骨领的部位可见具有破骨细胞形态特征的多核ED1阳性细胞。目前的发现支持破骨细胞是由来自血液单核细胞的单核吞噬细胞融合而来的观点。
SummaryThe origin of osteoclasts was studied in embryonic rat bone primordia using a set of monoclonal antibodies (ED1, ED2, and ED3) that exclusively recognize monocytes and macrophages. ED1 recognizes monocytes and macrophages. Mononuclear phagocytes which were ED1 positive were found in the perichondrium/periosteum of developing bone. These cells started to infiltrate the primordia when the cartilage became hypertrophic. During bone formation, multinucleated ED1-positive cells with the morphological characteristics of osteoclasts were found in the developing bone marrow cavity and against the bone collar. The present findings support the notion that osteoclasts arise by fusion of mononuclear phagocytes derived from blood monocytes.