Association of SOD1 and SOD2 single nucleotide polymorphisms with susceptibility to gastric cancer in a Korean population
Association of SOD1 and SOD2 single nucleotide polymorphisms with susceptibility to gastric cancer in a Korean population
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DOI：
10.1111/j.1600-0463.2012.02963.x
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发表时间：
2013-03-01
期刊：
影响因子：
2.8
通讯作者：
Park, Won Sang
中科院分区：
文献类型：
--
作者：
Han, Lin;Lee, Suk Woo;Park, Won Sang
韩L，李世伟，尹俊华，朴永国，蔡永俊，南瑞，李振英，王亚平，朴志秀。韩国人群中SOD1和SOD2单核苷酸多态与胃癌易感性的关系。APMIS2013；121：246-56.氧化应激被认为是癌症发生和发展的主要因素之一。超氧化物歧化酶(SODS)通过清除活性氧(ROS)在避免氧化应激中起着重要作用。为了确定SOD1基因G7958A和SOD2基因T5482C的单核苷酸多态是否与胃癌易感性增加相关，我们调查了294例胃癌患者和300名健康人的基因的基因型和等位基因频率。采用聚合酶链式反应-单链构象多态性分析方法鉴定SOD1G7958A和SOD2T5482C基因。SOD2T5482C的等位基因频率和等位基因频率在健康对照组和胃癌患者之间差异有统计学意义(P=0.0001和P
Han L, Lee SW, Yoon JH, Park YG, Choi YJ, Nam SW, Lee JY, Wang YP, Park WS. Association of SOD1 and SOD2 single nucleotide polymorphisms with susceptibility to gastric cancer in a Korean population. APMIS 2013; 121: 246-56.Oxidative stress is accepted as one of the main factors involved in the development and progression of cancer. Superoxide dismutases (SODs) are important in avoiding oxidative stress by eliminating reactive oxygen species (ROS). To determine whether single nucleotide polymorphisms at G7958A within SOD1 and at T5482C within SOD2 are associated with an increased susceptibility to gastric cancer, we investigated the genotype and allele frequencies of the genes from 294 gastric cancer patients and 300 healthy individuals. A polymerase chain reaction-single strand conformation polymorphism assay was used to identify the SOD1 G7958A and the SOD2 T5482C genotypes. Statistically significant differences in the genotype and allele frequencies of SOD2 T5482C were found between the healthy controls and gastric cancer patients (p=0.0001 and p