Immunoreactive-somatostatin, substance P, and calcitonin gene-related peptide concentrations of the human gastric mucosa in patients with nonulcer dyspepsia and peptic ulcer disease.
Immunoreactive-somatostatin, substance P, and calcitonin gene-related peptide concentrations of the human gastric mucosa in patients with nonulcer dyspepsia and peptic ulcer disease.
复制标题
非溃疡性消化不良和消化性溃疡病患者胃粘膜的免疫反应性生长抑素、P 物质和降钙素基因相关肽浓度。
DOI：
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发表时间：
1993
影响因子：
9.8
通讯作者：
K. Morise
中科院分区：
文献类型：
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作者：
H. Kaneko;T. Mitsuma;K. Uchida;A. Furusawa;K. Morise
在非溃疡性消化不良（NUD）和消化性溃疡受试者中，检测了人胃粘膜免疫反应（IR）-生长抑素、P物质和降钙素基因相关肽浓度的变化，以阐明这些肽与消化不良症状之间的关系。将五十六例NUD患者分为两个受试者亚组，如下所示：22例上腹部不适、恶心和/或呕吐患者（动力障碍组）和34例主诉上腹部疼痛的患者[溃疡样疾病（UD）组]。将这些患者与年龄和性别匹配的无任何器质性疾病的无症状门诊患者组（对照组：n = 51）或消化性溃疡组（PU组：n = 30）进行比较。UD组胃粘膜IR-生长抑素浓度显著高于PU组、动力障碍组和对照组，UD组IR-P物质浓度显著高于PU组。四组间未观察到ir-降钙素基因相关肽浓度的差异。这些结果表明，可能有两个不同的亚组在NUD，NUD不只是一个阶段的范围内的消化性溃疡疾病的观点，几个胃肠激素浓度的人胃粘膜。
Changes in immunoreactive (ir)-somatostatin, substance P, and calcitonin gene-related peptide concentrations of the human gastric mucosa were examined in subjects with nonulcer dyspepsia (NUD) and peptic ulcer to clarify the relationship between these peptides and dyspeptic symptoms. Fifty-six patients with NUD were divided into two subject subgroups as follows: 22 patients with upper abdominal discomfort, nausea, and/or vomiting (motility disorder group) and 34 patients complaining of upper abdominal pain [ulcer-like disorder (UD) group]. These patients were compared with either an age- and sex-matched group of asymptomatic outpatients without any organic disease (control group: n = 51), or to a group with peptic ulcer (PU group: n = 30). Ir-somatostatin concentrations of the gastric mucosa were significantly higher in UD group than in PU, motility disorder, or control group, and ir-substance P concentrations in the UD group were higher than in the PU group. No difference in ir-calcitonin gene-related peptide concentrations was observed among the four groups. These results indicate that there may be two distinct subgroups in NUD, and that NUD is not just a stage within the spectrum of peptic ulcer disease from the viewpoint of several gastrointestinal-hormone concentrations of the human gastric mucosa.