Events that regulate differentiation of αβ TCR+and γδ TCR+T cells from a common precursor
Events that regulate differentiation of αβ TCR+and γδ TCR+T cells from a common precursor
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调节 αβ TCR+ 和 γδ TCR+T 细胞从共同前体细胞分化的事件
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
D. Raulet
中科院分区：
文献类型：
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作者：
Joonsoo Kang;D. Raulet
T cells in vertebrates are composed of two distinct lineages of cells distinguished by the type of antigen receptors they express: the conventional population expresses TCR composed of alpha beta heterodimers while a smaller fraction of mature T cells displays gamma delta TCRs on the cell surface. The alpha beta and gamma delta T cells develop from common T-cell progenitors and the alpha beta/gamma delta lineage commitment process should be viewed in the context of the diverse cell fate decision processes crucial for normal cell differentiation from a single pluiripotent stem cell. A major focus in this field has been to determine the role of TCR gene rearrangement and expression in alpha beta/gamma delta lineage commitment. In this review we summarize the current state of understanding in the pattern of TCR gene rearrangement and expression of alpha beta and gamma delta T cells to address this central question of whether or not the lineage commitment is dictated by the state of TCR gene rearrangement.
