Actinomycin D: Inhibition of Respiration and Glycolysis
Actinomycin D: Inhibition of Respiration and Glycolysis
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Actinomycin D：抑制呼吸和糖酵解
作者：
J. Laszlo;Donald S. Miller;K. McCarty;P. Hochstein
放线菌素D抑制人白血病细胞的呼吸和无氧糖酵解，并降低细胞的三磷酸腺苷含量。在很宽的药物浓度范围内，对呼吸和RNA合成的抑制作用不能相互分离。放线菌素D也损害蛋白质合成，可能是通过减少三磷酸腺苷的可用性和抑制信使RNA。
Actinomycin D inhibited respiration and anaerobic glycolysis of human leukemic leukocytes and lowered the adenosine triphosphate content of the cells. Inhibitory effects on respiration and on RNA synthesis could not be dissociated from one another over a wide range of drug concentrations. Actinomycin D also impaired protein synthesis, probably by decreasing the availability of adenosine triphosphate and by inhibiting messenger RNA.