Method of detecting β-lactam antibiotic induced vancomycin resistant MRSA (BIVR)
Method of detecting β-lactam antibiotic induced vancomycin resistant MRSA (BIVR)
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DOI：
10.1016/j.ijantimicag.2003.05.018
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发表时间：
2004-01-01
影响因子：
10.8
通讯作者：
Sunakawa, K
中科院分区：
文献类型：
--
作者：
Hanaki, H;Yamaguchi, Y;Sunakawa, K
尽管已知万古霉素和β -内酰胺类抗生素联合使用对万古霉素敏感的金黄色葡萄球菌（VSSA）具有协同作用，但一些MRSA对万古霉素和β -内酰胺类抗生素联合使用表现出拮抗作用。这些MRSA被称为β -内酰胺抗生素诱导的万古霉素耐药MRSA （BIVR）。基于这种拮抗现象，设计了一种检测BIVR菌株的方法。该方法抑制了VSSA菌株，但允许BIVR菌株生长。46种市售β -内酰胺类抗生素诱导万古霉素耐药。使用这种检测方法，对来自日本8个研究所的717株MRSA临床分离株进行了筛选，其中6.3%在48小时的判断中被检测为BIVR。(C) 2003 Elsevier B.V.和国际化疗学会。版权所有。
Despite the fact that the combination of vancomycin and a beta-lactam antibiotic are known to act synergistically on vancomycin-susceptible Staphylococcus aureus (VSSA), some MRSA have emerged showing antagonism to the combination of vancomycin and a beta-lactam antibiotic. These MRSA are called beta-lactam antibiotic-induced vancomycin resistant MRSA (BIVR). A method based on this antagonistic phenomenon has been devised to detect BIVR strains. The method inhibits the VSSA strain but allows the BIVR strain to grow. Forty-six commercially available beta-lactam antibiotics induced the vancomycin-resistance. Using this detection method, 717 MRSA clinical isolates obtained from eight institutes throughout Japan were thus screened and 6.3% of these were detected as BIVR when judged at 48 h. (C) 2003 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.