Low-grade dietary-related inflammation and survival after colorectal cancer surgery
Low-grade dietary-related inflammation and survival after colorectal cancer surgery
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DOI：
10.1007/s00432-014-1711-6
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发表时间：
2014-09-01
影响因子：
3.6
通讯作者：
Kulig, Jan
中科院分区：
文献类型：
--
作者：
Galas, Aleksander;Kulig, Jan
长期炎症是在几种慢性疾病中观察到的一个中心过程，可能是生存的原因。越来越多的证据表明饮食在炎症中的作用，习惯性饮食可能是低度炎症的原因。我们研究的目的是评估通过饮食炎症指数（DII）测量的习惯性饮食的炎症特性对手术治疗的结直肠癌（CRC）患者的存活率的影响。在波兰的克拉科夫进行了689名手术治疗的CRC患者（平均年龄58岁，+/- 8.9; 56.7%为男性）的随访研究。习惯性饮食通过标准化半定量食物频率问卷进行评估。接下来，使用23种膳食项目来计算DII。研究表明，在接受化疗的癌症完全切除的CRC患者中，DII与生存时间呈线性相关（B =-0.13，p = 0.024）。在调整了几个重要的协变量后，DII与术后3年的生存率相关，但仅限于无远处转移的患者（3年HRDII >-2.27 = 0.61，95% CI 0.38-0.99）研究结果表明，DII可作为无远处转移患者手术治疗后生存率的潜在预测因子，《儿童权利公约》。
Prolong inflammation is a central process observed in several chronic conditions and may be responsible for survival. There is an increasing evidence showing the role of diet in inflammation and habitual diet may be responsible for low-grade inflammation. The purpose of our study was to assess the effect of inflammatory properties of habitual diet measured by the Dietary Inflammatory Index (DII) on survival among surgical patients treated for colorectal cancer (CRC).A follow-up study among 689 CRC patients (mean age 58 years, +/- 8.9; 56.7 % males) treated surgically was performed in Krakow, Poland. Habitual diet was assessed by a standardized semiquantitative food frequency questionnaire. Next, 23 dietary items were used to calculate DIIs. Vital records were verified to determine status of the participants.Study has shown linear association between DII and survival time among CRC patients with totally removed cancer treated by chemotherapy (b = -0.13, p = 0.024). After adjustment for several important covariates, DII was associated with survival during up to 3 years after surgery, but only in patients without distant metastases (3-year HRDII >-2.27 = 0.61, 95 % CI 0.38-0.99).The results of the investigation have shown the usefulness of the DII as a potential predictor of survival among patients without distant metastases treated surgically for CRC.