Meningococcal disease in Scandinavia.
Meningococcal disease in Scandinavia.
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斯堪的纳维亚半岛的脑膜炎球菌病。
DOI：
10.1136/bmj.284.6329.1618
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
I. Kallings
中科院分区：
文献类型：
--
作者：
H. Peltola;K. Jónsdóttir;A. Lystad;C. Sievers;I. Kallings
斯堪的纳维亚半岛（丹麦、芬兰、冰岛、挪威和瑞典）拥有共同边界和 2230 万居民，是一个社会经济和文化条件相似的地区。因此，流行病，例如脑膜炎球菌感染，可能会均匀分布。然而，1970-9 年 10 年期间的流行病学研究表明，发病率、年龄、血清型和类型分布以及疾病的总体动态存在显着差异。观察期内发生了三起流行病，其中两起由 B 组不同血清型（挪威和冰岛）引起，另一起由 A 组（芬兰）引起。年总发病率一般约为 3/100 000，但在流行期间从五倍（芬兰）增加到八倍（挪威北部）。这种流行毒株导致 3000 多名患者感染，并造成至少 250 人死亡。总体病死率为 8.6%（范围 4.1-13.7%）。与同年龄组的女性相比，男性更容易受到影响，且预后更差。芬兰的A组疫情受到大规模疫苗接种运动的影响，但这种可能性在其他两场疫情中并不可行。
Scandinavia (Denmark, Finland, Iceland, Norway, and Sweden) comprises with mutual borders and 22.3 million inhabitants an area where the socioeconomic and cultural conditions are similar. Epidemic diseases, such as meningococcal infection, might therefore be expected to be uniformly distributed. An epidemiological study in the 10-year period 1970-9 shows, however, remarkable differences in the incidence, age, and serogroup and type distribution, as well as in the general dynamics of the disease. Three epidemics, two caused by different serotypes of group B (Norway and Iceland) and one by group A (Finland) occurred within the observation period. The annual overall incidence was generally around 3/100 000 but increased from fivefold (Finland) to eightfold (northern Norway) during epidemics. The epidemic strains caused infection in over 3000 patients and the loss of at least 250 lives. The overall case fatality rate was 8.6% (range 4.1-13.7%). Men were more susceptible and had a worse prognosis than women of the same age group. The group A epidemic in Finland was influenced by a large vaccination campaign, but this possibility was not feasible in the two other epidemics.