RENIN, PRORENIN, AND IMMUNOREACTIVE RENIN IN VITREOUS FLUID FROM EYES WITH AND WITHOUT DIABETIC-RETINOPATHY
RENIN, PRORENIN, AND IMMUNOREACTIVE RENIN IN VITREOUS FLUID FROM EYES WITH AND WITHOUT DIABETIC-RETINOPATHY
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DOI：
10.1210/jcem-68-1-160
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发表时间：
1989-01-01
影响因子：
5.8
通讯作者：
SCHALEKAMP, MADH
中科院分区：
文献类型：
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作者：
DANSER, AHJ;VANDENDORPEL, MA;SCHALEKAMP, MADH
有和没有糖尿病视网膜病变的受试者的玻璃体和视网膜下液中均存在肾素、肾素原和免疫反应性肾素。在这些眼液中还发现了肾素底物、白蛋白、转铁蛋白和免疫球蛋白G。在许多样本中，肾素水平接近测定的检测限。在眼液样本中，肾素底物、白蛋白、转铁蛋白和免疫球蛋白G的水平变化很大，但在每个个体样本中，相对于彼此，水平与血浆中的水平相似。相比之下，眼液中的前肾素水平比基于眼液的血浆蛋白含量的预期高100倍。此外，血浆蛋白含量低和高的样本之间的前肾素浓度几乎没有差异。与白蛋白和其他血浆蛋白相比，伴有牵拉性视网膜脱离的增殖性糖尿病视网膜病变患者的玻璃体液中的前肾素水平高于非糖尿病自发性视网膜脱离患者。眼液中的前肾素（可能还有肾素）似乎是由一种活性和特异性过程控制的，可能是眼内的局部合成。鉴于血管紧张素II的血管作用，眼内肾素-血管紧张素系统可能在糖尿病视网膜病变中起作用。
Renin, prorenin, and immunoreactive renin were present in vitreous and subretinal fluid of eyes from subjects with and without diabetic retinopathy. Renin substrate, albumin, transferrin, and immunoglobin G were also found in these ocular fluids. In many samples renin levels were close to the detection limit of the assay. The levels of renin substrate, albumin, transferrin, and immunoglobulin G varied widely among ocular fluid samples, but in each individual sample the levels were, relative to each other, similar to those in plasma. In contrast, the prorenin level in ocular fluid was up to 100 times higher than expected on the basis of the plasma protein content of ocular fluid. Moreover, there was little difference in prorenin concentrations between samples with low and high plasma protein contents. Prorenin, relative to albumin and other plasma proteins, was higher in vitreous fluid from eyes with proliferative diabetic retinopathy complicated by traction retinal detachment than in eyes of nondiabetic subjects with spontaneous retinal detachment. It appears that prorenin (and possibly renin) in ocular fluid is controlled by an active and specific process, possibly local synthesis within the eye. In view of the vascular actions of angiotensin II, an intraocular renin-angiotensin system may play a role in diabetic retinopathy.