Prognostic value of β-catenin, c-myc, and cyclin D1 expressions in patients with esophageal squamous cell carcinoma
Prognostic value of β-catenin, c-myc, and cyclin D1 expressions in patients with esophageal squamous cell carcinoma
复制标题
DOI：
10.1007/s12032-010-9436-0
复制
发表时间：
2011-03-01
期刊：
影响因子：
3.4
通讯作者：
Wang, Pengju
中科院分区：
文献类型：
--
作者：
Wang, Wei;Xue, Lexun;Wang, Pengju
食管鳞状细胞癌是我国北方地区最常见的恶性肿瘤之一。我们已经发现Wnt 2/beta-catenin通路在ESCC细胞中被激活，硝普钠（SNP）和针对beta-catenin的siRNA不仅抑制beta-catenin及其主要下游效应物（包括c-myc和cyclin D1）的表达，而且诱导细胞周期停滞和凋亡。本研究旨在分析食管鳞癌组织中β-catenin、c-myc和cyclin D1的表达与浸润深度、淋巴结转移等病理参数的关系，探讨其对食管鳞癌患者预后的价值。采用免疫组化法检测40例食管鳞癌患者手术切除的癌组织中β-catenin、c-myc和cyclin D1的表达。22例（55.0%）患者β-catenin表达降低，与浸润深度（P = 0.023）和淋巴结转移（P = 0.003）密切相关。c-myc阳性表达21例（52.5%），与浸润深度（P = 0.009）和淋巴结转移（P = 0.001）显著相关。Kaplan-Meier曲线分析生存率结果显示，β-catenin表达降低的患者预后明显差于β-catenin表达维持的患者（P = 0.031），c-myc表达阳性的患者预后明显差于c-myc表达阴性的患者（P = 0.008）。提示β-catenin和c-myc在食管鳞癌的发生、发展中起重要作用，可作为预测食管鳞癌患者预后的指标。
Esophageal squamous cell carcinoma (ESCC) is one of the most frequently diagnosed malignant tumors in North China. We have identified that Wnt2/beta-catenin pathway is activated in ESCC cells and sodium nitroprusside (SNP) and siRNA against beta-catenin not only inhibit the expressions of beta-catenin and its major downstream effectors including c-myc and cyclin D1 but induce cell cycle arrest and apoptosis. The purpose of the present study was to analyze the relationship between pathological parameters including invasion depth and lymph node metastasis and the expressions of beta-catenin, c-myc, and cyclin D1 in order to evaluate their values of prognosis in patients with ESCC. The expressions of beta-catenin, c-myc, and cyclin D1 were detected immunohistochemically in the resected cancer tissues from 40 patients with ESCC. The beta-catenin expression was reduced in 22 (55.0%) patients, which was closely correlated with invasion depth (P = 0.023) and lymph node metastasis (P = 0.003). There was the positive c-myc expression in 21 (52.5%), which was significantly correlated with invasion depth (P = 0.009) and lymph node metastasis (P = 0.001). Furthermore, the results of survival rates analyzed by Kaplan-Meier curve revealed that patients with the reduced expression of beta-catenin had a poorer prognosis than those with the preserved expression (P = 0.031), and patients with the positive expression of c-myc also had a significantly poorer prognosis than those with the negative expression (P = 0.008). These findings demonstrate that beta-catenin pathway plays a crucial role in the progression of ESCC, suggesting that both beta-catenin and c-myc may be used as markers for predicting the prognosis of patients with ESCC.