Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer.
Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer.
复制标题
草药配方 YYJD 通过诱导肺癌细胞周期停滞和衰老来抑制肿瘤生长
DOI：
10.1038/s41598-017-05146-x
复制
发表时间：
2017-07-10
影响因子：
4.6
通讯作者：
Xu L
中科院分区：
文献类型：
--
作者：
Zheng T;Que Z;Jiao L;Kang Y;Gong Y;Yao J;Ma C;Bi L;Dong Q;Zhao X;Xu L
肺癌是世界范围内癌症相关死亡的主要原因。尽管各种治疗策略和抗肿瘤药物已被用于提高疗效，但肺癌患者的五年生存率仍然很低。在这项研究中，我们研究了我们最近优化的中药复方养阴解毒（YYJD）对肺癌的作用和潜在机制。养阴解毒汤对肺癌细胞株（95-D、A549、H460和H1975）的增殖有明显的抑制作用，并呈剂量依赖性。特别是，YYJD诱导显著的G2/M期阻滞并抑制肺癌细胞的殖民地形成。此外，我们发现，给予YYJD可以抑制肺癌细胞在裸鼠移植瘤中的生长，而体重没有减轻。我们的研究结果表明，中药复方YYJD是一个潜在的抗肿瘤剂对肺癌。
Lung cancer represents a major cause of cancer-related death worldwide. Although various tactics and anti-tumor drugs have been used to improve curative effects, five-year survival rate of lung cancer patients remains poor. In this study, we investigated the action and underlying mechanisms of our recently optimized Chinese herbal formula Yangyinjiedu (YYJD) against lung cancer. YYJD significantly inhibits the proliferation of lung cancer cell lines (95-D, A549, H460 and H1975) by inducing cell cycle arrest and senescence in a dose-dependent manner. In particular, YYJD induces significant G2/M phase arrest and inhibits the colony formation of lung cancer cells. Moreover, we found that administration of YYJD could inhibit the growth of xenografted lung cancer cells in nude mice without loss in body weight. Our findings suggest that the herbal formula YYJD is a potential anti-tumor agent against lung cancer.