Direct viewing of atherosclerosis in vivo: plaque invasion by leukocytes is initiated by the endothelial selectins
Direct viewing of atherosclerosis in vivo: plaque invasion by leukocytes is initiated by the endothelial selectins
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DOI：
10.1096/fj.00-0537com
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发表时间：
2001-05-01
期刊：
影响因子：
4.8
通讯作者：
Lindbom, L
中科院分区：
文献类型：
--
作者：
Eriksson, EE;Xie, X;Lindbom, L
利用组织学技术对动脉粥样硬化中的白细胞渗透进行了广泛的研究。在这项研究中，我们对动脉粥样硬化小鼠的动脉内白细胞募集进行了活体显微镜观察。白细胞和动脉粥样硬化内皮细胞之间的相互作用是高度短暂的，从而限制了滚动的白细胞牢固黏附的能力。抑制P-选择素的功能可抑制白细胞滚动(P
Leukocyte infiltration in atherosclerosis has been extensively investigated by using histological techniques on fixed tissues. In this study, intravital microscopic observations of leukocyte recruitment in the aorta of atherosclerotic mice were performed. Interactions between leukocytes and atherosclerotic endothelium were highly transient, thereby limiting the ability for rolling leukocytes to firmly adhere. Leukocyte rolling was abolished by function inhibition of P-selectin (P