Identification of erythropoietin producing cells in fetal mouse liver cultures.
Identification of erythropoietin producing cells in fetal mouse liver cultures.
复制标题
胎鼠肝脏培养物中促红细胞生成素产生细胞的鉴定。
作者：
D. Gruber;J. Zucali;E. Mirand
培养胎鼠肝脏外植体，培养基显示出具有可被绵羊血浆促红细胞生成素抗血清中和的促红细胞生成活性物质，表明培养基含有促红细胞生成素。免疫荧光和碳颗粒摄入技术表明促红细胞生成素是由肝网状内皮系统的巨噬细胞或库普弗细胞精心制作的。
Fetal mouse liver explants were cultured and the culture media shown to possess an erythropoietically active substance neutralizable by antiserum to sheep plasma erythropoietin, suggesting that the media contain erythropoietin. Immunofluorescent and carbon particle ingestion techniques suggest that the erythropoietin was elaborated by macrophages or Kupffer cells of the hepatic reticuloendothelial system.