Antidepressant-like and anxiolytic-like effects of hydrogen sulfide in behavioral models of depression and anxiety
Antidepressant-like and anxiolytic-like effects of hydrogen sulfide in behavioral models of depression and anxiety
复制标题
硫化氢在抑郁和焦虑行为模型中具有抗抑郁样和抗焦虑样作用。
DOI：
10.1097/fbp.0b013e3283654258
复制
发表时间：
2013-10-01
影响因子：
1.6
通讯作者：
Tian, Ying
中科院分区：
文献类型：
--
作者：
Chen, Wen-Lin;Xie, Bin;Tian, Ying
抑郁症是一种常见的使人衰弱的精神疾病，通常与焦虑症共病。突触可塑性改变被认为是抗抑郁药物作用的重要机制。有研究表明，硫化氢（H2S）作为第三种气体递质，促进海马长时程增强的诱导，增强突触神经传递，参与突触可塑性的调节。本研究的目的是阐明H2S的抗抑郁样和抗焦虑样作用。H_2S（NaHS，1.68或5.6mg/kg，腹腔注射，连续7天）在小鼠和大鼠强迫游泳实验和小鼠悬尾实验中具有特异性抗抑郁样作用，在高架十字迷宫实验中能减少小鼠和大鼠的焦虑样行为。这些结果揭示了H2S在抑郁样和焦虑样行为中的独特拮抗作用，并表明提高大脑中的H2S信号传导可能代表了治疗抑郁和焦虑障碍的新方法。
Depression is a common and debilitating mental illness and is often comorbid with anxiety disorders. Altered synaptic plasticity is considered to be an important mechanism underlying antidepressant drug action. It has been reported that hydrogen sulfide (H2S), the third gaseous transmitter, facilitates the induction of hippocampal long-term potentiation and augments synaptic neurotransmission, involved in the regulation of synaptic plasticity. The aim of this study was to clarify the antidepressant-like and anxiolytic-like effects of H2S. H2S (NaHS, 1.68 or 5.6 mg/kg, intraperitoneally, for 7 days) exerts a specific antidepressant-like effect in the forced swimming test of mice and rats and the tail suspension test of mice, and reduces the anxiety-like behaviors of both mice and rats in the elevated plus-maze test. These results reveal a unique antagonistic action of H2S in depressive-like and anxiety-like behaviors and suggest that elevating H2S signaling in the brain may represent a novel approach for the treatment of depressive and anxiety disorders.