Hippocampal low-frequency stimulation improves the cognitive function of pharmacoresistant epileptic rats.
Hippocampal low-frequency stimulation improves the cognitive function of pharmacoresistant epileptic rats.
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DOI：
10.1016/j.eplepsyres.2019.106194
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Guofeng Wu
中科院分区：
文献类型：
--
作者：
Likun Wang;Haiyan Shi;Yangting Kang;Guofeng Wu
Objective: The aims of the present study were to observe the changes of cognitive function in a pilocarpineinduced.rat model of epilepsy, and to investigate the effects of hippocampal low-frequency stimulation (Hip-LFS).on cognitive function in rats with pharmacoresistant epilepsy..Methods: A total of 100 male Sprague Dawley rats were randomly selected to establish an epilepsy model. Rats.with successfully induced epilepsy were injected intraperitoneally with phenobarbital and phenytoin for pharmacoresistance.selection. The selected pharmacoresistant epileptic (PRE) rats were assigned to a pharmacoresistant.control group (PRC group), or a group that received Hip-LFS (LFS group). The same number of rats with.pharmacosensitive epilepsy formed the PSC group, and a normal control (NCR) group was included. A novel.object recognition (NOR) test, and a Morris water maze (MWM) task were used to assess cognitive function in all.groups..Results: The epileptic rats showed decreased abilities of learning and memory compared with normal control..The rats in the LFS group displayed significantly shorter escape latency in place navigation, spent longer times in.the target quadrant, and traveled longer distances on the platform in the spatial probe test than PRC group. In.the NOR test, compared with the PRC group, the discrimination index of the LFS group was significantly increased..Compared with the PRC group, the average frequency and duration of seizures were also decreased in.the LFS group..Conclusions: The present pilocarpine-induced rat model of epilepsy showed impaired cognitive function, especially.in rats with PRE. The Hip-LFS treatment could effectively improve the cognitive function of rats with PRE.
