RED-CELL AUTOANTIBODIES IN PATIENTS WITH ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME
RED-CELL AUTOANTIBODIES IN PATIENTS WITH ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME
复制标题
DOI：
10.1046/j.1537-2995.1986.26587020112.x
复制
发表时间：
1986-09-01
期刊：
影响因子：
2.9
通讯作者：
ALTER, HJ
中科院分区：
文献类型：
--
作者：
MCGINNISS, MH;MACHER, AM;ALTER, HJ
在获得性免疫缺陷综合征（AIDS）患者中观察到轻度至重度贫血、血小板减少和罕见的中性粒细胞减少。为了研究可能的免疫机制，对28名住院艾滋病患者、4名无症状同性恋男性、4名患有艾滋病相关淋巴结病综合征的同性恋男性、30名非艾滋病住院患者和60名献血者的血液样本进行了非典型红细胞抗体检测。18例艾滋病患者（64%）有抗-i，9例（32%）有自身抗-U，12例（43%）有阳性的直接抗球蛋白试验。一名无症状男同性恋者及三名有淋巴结病男同性恋者亦有抗i抗体。相比之下，30例非艾滋病患者和60名献血者中，无一人抗U或直接抗球蛋白试验阳性。1例镰状细胞病患者有抗i。有抗-i或抗-U抗体的AIDS患者的平均血红蛋白水平显著低于无这些抗体的患者的平均血红蛋白水平。
Mild-to-profound anemia, thrombocytopenia, and rarely neutropenia have been observed in patients with the acquired immune deficiency syndrome (AIDS). To investigate a possible immune mechanism, blood samples from 28 hospitalized AIDS patients, four asymptomatic homosexual men, four homosexual men with the AIDS-related lymphadenopathy syndrome, 30 hospitalized patients with diseases other than AIDS, and 60 blood donors were tested for the presence of atypical red cell antibodies. Eighteen AIDS patients (64%) had anti-i, nine (32%) had autoanti-U, and 12 (43%) had a positive direct antiglobulin test. One asymptomatic homosexual man and three homosexual men with lymphadenopathy also had anti-i. In contrast, of the 30 patients with diseases other than AIDS and 60 donors, none had anti-U or a positive direct antiglobulin test. One patient with sickle cell disease had anti-i. The mean hemoglobin level of AIDS patients with anti-i or anti-U was significantly lower than the mean hemoglobin level of patients who did not have those antibodies.