In vivo study of the anti-inflammatory and antitumor activities of leaves from Plectranthus amboinicus (Lour.) Spreng (Lamiaceae)
In vivo study of the anti-inflammatory and antitumor activities of leaves from Plectranthus amboinicus (Lour.) Spreng (Lamiaceae)
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DOI：
10.1016/j.jep.2009.07.006
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发表时间：
2009-09-07
影响因子：
5.4
通讯作者：
Souza, Ivone A.
中科院分区：
文献类型：
--
作者：
Diniz Gurgel, Ana Pavla A.;da Silva, Jackeline G.;Souza, Ivone A.
民族药理学相关性：香茶（Plectanthus amboinicus（Lour.）Spreng是一种药用物种，经常在巴西使用，特别是在东北地区，用于治疗包括炎症和癌症在内的几种疾病。研究目的：评价P. amboinicus叶的水醇提取物的抗炎和抗肿瘤活性，以确定其药用用途是否得到药理作用的支持。材料和方法：角叉菜胶致足肿胀法测定抗炎活性。在体内实验研究中，使用以下肿瘤评估抗肿瘤效果：肉瘤-180和埃利希腹水癌。结果：在150、250和350 mg/kg（i. p.）的水醇提取物。类似地，以100、150、250和350 mg/kg（i. p.）结论：黄柏水醇提取物具有抗炎和抗肿瘤活性，为黄柏的民间应用提供了依据。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Ethnopharmacological relevance: Plectranthus amboinicus (Lour.) Spreng is a medicinal specie often used in Brazil, especially in Northeast Region, for the treatment of several diseases including inflammations and cancer.Aim of the study: To evaluate the anti-inflammatory and antitumor activities of the hydroalcoholic extract from leaves of P. amboinicus in an attempt to determine whether the medicinal uses are supported by pharmacological effects.Materials and methods: Anti-inflammatory activity was determined by carrageenan-induced paw edema method. The antitumor effect was evaluated in an in vivo experimental study, using the following tumors: Sarcoma-180 and Erlich ascite carcinoma.Results: There were statistically significant decreases (p < .05) of edema paw in at the doses of 150, 250 and 350 mg/kg (i.p.) of the hydroalcoholic extract of P. amboinicus. Similarly, the administration of P. amboinicus at the doses of 100, 150, 250 and 350 mg/kg (i.p.) inhibited the growth of sarcoma-180 and Ehrlich ascite carcinoma tumors in mice.Conclusion: The results suggest that the hydroalcoholic extract of P. amboinicus possesses anti-inflammatory and antitumor activities, supporting the folk use of this medicinal specie. (C) 2009 Elsevier Ireland Ltd. All rights reserved.