Gastrointestinal dysfunction in neurological disease: a report of an interdisciplinary international symposium
Gastrointestinal dysfunction in neurological disease: a report of an interdisciplinary international symposium
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神经系统疾病中的胃肠功能障碍：跨学科国际研讨会报告
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
R. Pfeiffer
中科院分区：
文献类型：
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作者：
E. Quigley;R. Pfeiffer
1993年9月22日和23日，一群基础科学家、神经学家和胃肠病学家聚集在美国内布拉斯加州奥马哈，讨论神经系统疾病中的胃肠功能障碍。尽管胃肠道症状和明显的肠道功能障碍在各种神经系统疾病患者中很常见，但其病理生理学、评估和管理尚未受到极大关注，并且现有信息分散在各种期刊和专著中，这一事实不会鼓励寻求这一领域信息或指导的研究者或临床医生：因此，组织本次研讨会的动力。第一次会议是专门概述了'基本胃神经'的目标是设置阶段的临床主题遵循。关于通过中枢神经系统[Richard Gillis，Georgetown University，华盛顿，DC，USA]和肠神经系统（Jeffrey Conklin，University of爱荷华州，爱荷华州City，IA，USA）调节肠道功能的报告揭示了我们对肠道运动功能的各种控制水平的理解的巨大爆炸。中枢神经系统（CNS）内与各种胃肠运动功能相关的细胞核和神经元通路的清楚描述为理解各种神经系统疾病中遇到的胃肠功能障碍的病理生理学提供了明确的基础，这是研讨会稍后几位发言者返回的主题。类似地，可以由肠道固有的神经系统（肠神经系统）启动和调节的那些肠道功能的描述已经被证明是有效的。
On 22 and 23 September 1993, a group of basic scientists, neurologists and gastroenterologists came together in Omaha, Nebraska, USA, to discuss gastrointestinal dysfunction in neurological disease. Though gastrointestinal symptoms and overt gut dysfunction are common among patients with a variety of neurological disorders, their pathophysiology, evaluation and management have not received great attention and the investigator or clinician seeking information or guidance in this area will not be encouraged by the fact that available information is dissipated among a diverse array of journals and monographs: hence the impetus to organize this symposium. The first session was devoted to overviews of ‘Basic Gastroneurology’ the goal being to set the stage for the clinical topics to follow. Presentations on the modulation of gut function via the central nervous system [Richard Gillis, Georgetown University, Washington, DC, USA) and the enteric nervous system (Jeffrey Conklin, University of Iowa, Iowa City, IA, USA) revealed the tremendous explosion in our understanding of the various levels of control of gut motor function, in particular. The clear description of the nuclei and neuronal pathways within the central nervous system (CNS) associated with various gastrointestinal motor functions provides a clear basis for the understanding of the pathophysiology of gastrointestinal dysfunctions encountered in various neurological diseases, a theme returned to by several speakers later in the symposium. Similarly, the delineation of those gut functions which can be initiated and modulated by the nervous system intrinsic to the gut (the enteric nervous system) has