Parathyroid hormone acutely increases polyphosphoinositides of the rabbit kidney cortex by a cycloheximide-sensitive process.
Parathyroid hormone acutely increases polyphosphoinositides of the rabbit kidney cortex by a cycloheximide-sensitive process.
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甲状旁腺激素通过放线菌酮敏感过程急剧增加兔肾皮质的多磷酸肌醇。
DOI：
10.1172/jci109818
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
R. Larson
中科院分区：
文献类型：
--
作者：
R. Farese;P. Bidot;A. Sabir;J. S. Smith;B. Schinbeckler;R. Larson
甲状旁腺激素（PTH）能迅速增加兔肾皮质二磷酸肌醇和三磷酸肌醇的浓度。放线菌酮预处理消除了PTH的这些影响。这些发现与肾上腺皮质中促肾上腺皮质激素和环AMP作用的报道相似，并提示了一种共同的机制。PTH的环己酰亚胺敏感效应，例如，磷酸尿症可能需要多磷酸肌醇和/或其他磷脂。
Parathyroid hormone(PTH) rapidly increases the concentrations of diphosphoinositide and triphosphoinositide in rabbit kidney cortex. Cycloheximide pretreatment abolishes these effects of PTH. These findings are similar to those reported for adrenocorticotropin and cyclic AMP action in the adrenal cortex, and suggest a common mechanism. Cycloheximide-sensitive effects of PTH, e.g., phosphaturia, may require polyphosphoinositides and/or other phospholipids.