Age-related differences in ventral striatal and default mode network function during reciprocated trust.
Age-related differences in ventral striatal and default mode network function during reciprocated trust.
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DOI：
10.1016/j.neuroimage.2022.119267
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发表时间：
2022-08-01
期刊：
影响因子：
5.7
通讯作者：
Smith, David, V
中科院分区：
文献类型：
--
作者：
Fareri, Dominic S.;Hackett, Katherine;Tepfer, Lindsey J.;Kelly, Victoria;Henninger, Nicole;Reeck, Crystal;Giovannetti, Tania;Smith, David, V
随着社交网络的缩小和动机优先级的转移，社会关系在整个生命周期中都会发生变化。有趣的是，衰老也与执行功能的变化有关，包括决策能力，但目前尚不清楚这两个领域中与年龄相关的变化如何相互作用，影响涉及其他人的财务决策。为了研究这个问题，我们招募了50名人类参与者（Nyounger = 26，年龄18-34岁; Norder = 24，年龄63-80岁）作为投资者与三个合作伙伴（朋友，陌生人和计算机）扮演被投资者的角色进行经济信任游戏。在信任游戏期间，投资者接受了功能性磁共振成像（fMRI），而被投资者则坐在扫描仪外面。基于我们之前对年轻人的研究，在互惠信任过程中，作为社会亲密度的函数，年轻人的纹状体反应增强，默认模式网络（DMN）连接改变，我们预测这些关系将表现出与年龄相关的差异。我们发现，相对于年轻人，老年人对来自朋友相对于陌生人和计算机的相互信任的纹状体反应是迟钝的，从而支持了我们关于社会亲密度的主要预注册假设。我们还发现，老年人表现出增强的DMN连接与颞顶交界处（TPJ）在互惠信任的朋友相比，计算机，而年轻人表现出相反的模式。总之，这些结果推进了我们对在信任他人的背景下对社会亲密度敏感性的年龄相关差异的理解。
Social relationships change across the lifespan as social networks narrow and motivational priorities shift to the present. Interestingly, aging is also associated with changes in executive function, including decision-making abilities, but it remains unclear how age-related changes in both domains interact to impact financial decisions involving other people. To study this problem, we recruited 50 human participants (Nyounger = 26, ages 18–34; Nolder = 24, ages 63–80) to play an economic trust game as the investor with three partners (friend, stranger, and computer) who played the role of investee. Investors underwent functional magnetic resonance imaging (fMRI) during the trust game while investees were seated outside of the scanner. Building on our previous work with younger adults showing both enhanced striatal responses and altered default-mode network (DMN) connectivity as a function of social closeness during reciprocated trust, we predicted that these relations would exhibit age-related differences. We found that striatal responses to reciprocated trust from friends relative to strangers and computers were blunted in older adults relative to younger adults, thus supporting our primary pre-registered hypothesis regarding social closeness. We also found that older adults exhibited enhanced DMN connectivity with the temporoparietal junction (TPJ) during reciprocated trust from friends compared to computers while younger adults exhibited the opposite pattern. Taken together, these results advance our understanding of age-related differences in sensitivity to social closeness in the context of trusting others.
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