Development of different phenotypes of hypertensive heart failure: systolic versus diastolic failure in Dahl salt-sensitive rats
Development of different phenotypes of hypertensive heart failure: systolic versus diastolic failure in Dahl salt-sensitive rats
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DOI：
10.1097/00004872-200018010-00016
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发表时间：
2000-01-01
影响因子：
4.9
通讯作者：
Hori, M
中科院分区：
文献类型：
--
作者：
Doi, R;Masuyama, T;Hori, M
目的心力衰竭有两种表型，即收缩性心衰和单纯性舒张性心衰并保留左心室收缩功能。虽然孤立性舒张性心力衰竭经常发生，但只有与心力衰竭无关的舒张性功能障碍模型和明显的舒张性心力衰竭模型尚未建立。我们试图建立两种不同的高血压模型，即舒张期和收缩期衰竭模型。材料与方法Dahl盐敏感大鼠从7周龄(7周龄)或8周龄(8周龄)开始给予8%氯化钠饮食。作为年龄匹配的对照组，Dahl盐敏感大鼠一直被置于正常饮食中。结果7周开始的大鼠出现血压急剧升高和进行性左室肥厚，约19周时出现明显的心力衰竭。与年龄匹配的对照组相比，心力衰竭的发生与左室中壁缩短分数的减少或左室舒张末期内径的增加无关，这与临床观察到的孤立性舒张性心力衰竭的特征相似。8周开始的大鼠血压逐渐升高，左心室肥厚进展较慢，约26周时陷入心力衰竭，中壁缩短率降低，左室舒张末期内径增加。衰竭期的血流动力学和组织学检查显示两组患者的左心室舒张末压升高和左心室纤维化程度相当。结论这两种不同的显性心力衰竭模型可分别作为同一高血压心脏病基础上的单纯舒张性心力衰竭和收缩期心衰的模型，有助于区分两种不同表型心力衰竭的发生机制。J Hyperten 2000，18：111-120(C)Lippincott Williams&Wilkins.
Objective There are two phenotypes of heart failure, systolic failure and isolated diastolic heart failure with preserved left ventricular systolic function. Although isolated diastolic heart failure frequently occurs, there are only models for diastolic dysfunction unassociated with heart failure and models with overt diastolic heart failure have not been established. We attempted to develop two different models, i.e. diastolic and systolic failure models, based on hypertension.Materials and methods Dahl salt-sensitive rats were placed on 8% NaCl diet from 7 weeks old (7-week starting group) or 8 weeks old (8-week starting group). As an age-matched control, Dahl salt-sensitive rats were consistently placed on normal chow. In these rats, echocardiogram was serially recorded, followed by hemodynamic and histological studies.Results The 7-week starting rats showed a steep elevation in blood pressure and progressive left ventricular hypertrophy, and fell into overt heart failure at approximately 19 weeks. The development of heart failure was not associated with a decrease in left ventricular midwall fractional shortening or an increase in left ventricular end-diastolic dimension as compared with the age-matched control, which mimics the characteristics of clinically observed isolated diastolic heart failure. The 8-week starting rats showed a gradual rise in blood pressure and less progressive left ventricular hypertrophy, and fell into heart failure at approximately 26 weeks with a decrease in mid-wall fractional shortening and an increase in left ventricular end-diastolic dimension. Hemodynamic and histological studies at failing stage revealed comparable elevation of left ventricular end-diastolic pressure and comparable left ventricular fibrosis in both groups,Conclusion These two different models of overt heart failure may be useful as models of isolated diastolic heart failure and systolic heart failure based on the same hypertensive heart disease, respectively, and may contribute to discrimination of the mechanisms of the development of the two different phenotypes of heart failure. J Hypertens 2000, 18:111-120 (C) Lippincott Williams & Wilkins.