Bioactive and biodegradable nanocomposites and hybrid biomaterials for bone regeneration.
Bioactive and biodegradable nanocomposites and hybrid biomaterials for bone regeneration.
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DOI：
10.3390/jfb3020432
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发表时间：
2012-06-20
影响因子：
4.8
通讯作者：
Rizkalla AS
中科院分区：
文献类型：
--
作者：
Allo BA;Costa DO;Dixon SJ;Mequanint K;Rizkalla AS
骨组织工程和再生的策略依赖于生物活性支架来模拟天然细胞外基质，并作为细胞附着、繁殖、迁移和功能的模板。特别感兴趣的是纳米复合材料和有机-无机（O/I）杂化生物材料，基于可生物降解聚合物和生物活性无机材料的选择性组合。本文综述了生物活性和可生物降解的纳米复合材料和O/I杂化生物材料的研究现状及其在骨再生中的应用。我们特别关注基于纳米羟基磷灰石（HA）和生物活性玻璃（BG）填料与可生物降解聚酯及其杂交对应物结合的纳米复合材料。主题包括3D支架设计，骨再生中广泛使用的材料，以及下一代生物材料的最新趋势。最后展望了纳米复合材料和O/I混合生物材料在骨再生中的应用前景。
Strategies for bone tissue engineering and regeneration rely on bioactive scaffolds to mimic the natural extracellular matrix and act as templates onto which cells attach, multiply, migrate and function. Of particular interest are nanocomposites and organic-inorganic (O/I) hybrid biomaterials based on selective combinations of biodegradable polymers and bioactive inorganic materials. In this paper, we review the current state of bioactive and biodegradable nanocomposite and O/I hybrid biomaterials and their applications in bone regeneration. We focus specifically on nanocomposites based on nano-sized hydroxyapatite (HA) and bioactive glass (BG) fillers in combination with biodegradable polyesters and their hybrid counterparts. Topics include 3D scaffold design, materials that are widely used in bone regeneration, and recent trends in next generation biomaterials. We conclude with a perspective on the future application of nanocomposites and O/I hybrid biomaterials for regeneration of bone.