Spatiotemporal Circulation of Influenza Viruses in 5 African Countries During 2008-2009: A Collaborative Study of the Institut Pasteur International Network
Spatiotemporal Circulation of Influenza Viruses in 5 African Countries During 2008-2009: A Collaborative Study of the Institut Pasteur International Network
复制标题
DOI：
10.1093/infdis/jis541
复制
发表时间：
2012-12-15
影响因子：
6.4
通讯作者：
Diop, Ousmane Madiagne
中科院分区：
文献类型：
--
作者：
Heraud, Jean-Michel;Njouom, Richard;Diop, Ousmane Madiagne
背景虽然最近的工作已经描述了流感病毒在世界范围内的时空扩散，但仍然缺乏关于非洲大陆和马达加斯加流感时空模式的全面数据。来自喀麦隆、科特迪瓦、马达加斯加、尼日尔和塞内加尔5个国家的国家流感中心从2年期间（2008-2009年）到哨点监测诊所就诊的流感样疾病患者中采集标本。分离株的遗传和抗原特性。总共测试了8312个样本。在329、689和148份标本中分别检测到季节性甲型流感病毒亚型H1N1和H3 N2以及流感B病毒。2009年，在马达加斯加发现的甲型流感病毒亚型H1N1最常见（占病例的98.5%）。在我们评估的非洲国家中，流感活动要么是全年显著，要么是在一年中的特定时期发生。我们的研究结果表明，从马达加斯加到塞内加尔，流感病毒的流行病学和病毒学特征是不同的时空循环的不同病毒类型，亚型和菌株。我们的数据强调了针对具体国家的监测以及数据和病毒共享的重要性，它们为帮助决策者制定战略提供了合理的基础，例如在正确的时间和正确的配方接种疫苗，旨在减少非洲和马达加斯加的疾病负担。
Background. Although recent work has described the spatiotemporal diffusion of influenza viruses worldwide, comprehensive data on spatiotemporal patterns of influenza from the African continent and Madagascar are still lacking.Methods. National Influenza Centers from 5 countries-Cameroon, Cote d'Ivoire, Madagascar, Niger, and Senegal-collected specimens from patients presenting with influenza-like illness who visited sentinel surveillance clinics during a 2-year period (2008-2009). Isolates were genetically and antigenically characterized.Results. Overall, 8312 specimens were tested. Seasonal influenza A virus subtypes H1N1 and H3N2 and influenza B viruses were detected in 329, 689, and 148 specimens, respectively. In 2009, pandemic influenza A virus subtype H1N1 was detected in Madagascar most commonly (98.5% of cases). Influenza activity was either significant year-round or occurred during a specific period of the year in the African countries we evaluated.Conclusions. Our results demonstrate that, from Madagascar to Senegal, the epidemiologic and virologic characteristics of influenza viruses are diverse in terms of spatiotemporal circulation of the different virus types, subtypes, and strains. Our data highlight the importance of country-specific surveillance and of data and virus sharing, and they provide a rational basis to aid policy makers to develop strategies, such as vaccination at the right moment and with the right formulation, aimed at reducing the disease burden in Africa and Madagascar.