Propranolol hydrochloride induces neurodevelopmental toxicity and locomotor disorders in zebrafish larvae
Propranolol hydrochloride induces neurodevelopmental toxicity and locomotor disorders in zebrafish larvae
复制标题
盐酸普萘洛尔诱导斑马鱼幼虫神经发育毒性和运动障碍
DOI：
10.1016/j.neuro.2022.10.016
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发表时间：
2022-11-03
期刊：
影响因子：
3.4
通讯作者：
Cao, Zigang
中科院分区：
文献类型：
--
作者：
Li, Xue;Liao, Xinjun;Cao, Zigang
Propranolol hydrochloride is the first-line drug for the clinical treatment of hypertension, arrhythmia, and other diseases. However, with the increasing use of this drug, its safety and environmental health have received more and more attention. In this study, aquatic vertebrate zebrafish were used as a model to study the toxic effects and mechanisms of propranolol hydrochloride. It was revealed that zebrafish larvae exposed to propranolol hydro-chloride showed aberrant head nerve development and locomotor disorders. Additionally, exposure to pro-pranolol hydrochloride could induce oxidative stress, alter the activities of AChE and ATPase, and disrupt the expression of genes involved in neurodevelopment and neurotransmitter pathways. More interestingly, the expression of Parkinson's disease-related genes was altered in zebrafish treated with propranolol hydrochloride. We detected the expression of genes related to the Wnt signaling pathway and found that their expression appeared to be down-regulated. The phenotype of nerve developmental defects and locomotor disorders can be effectively rescued by astaxanthin and Wnt activators. Collectively, the results suggest that propranolol hydro-chloride may induce neurotoxicity and abnormal movement behavior with PD-like symptoms in zebrafish larvae.
