Dietary flavonoid intake and weight maintenance: three prospective cohorts of 124,086 US men and women followed for up to 24 years.
Dietary flavonoid intake and weight maintenance: three prospective cohorts of 124,086 US men and women followed for up to 24 years.
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DOI：
10.1136/bmj.i17
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发表时间：
2016-01-28
期刊：
影响因子：
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通讯作者：
Cassidy A
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文献类型：
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作者：
Bertoia ML;Rimm EB;Mukamal KJ;Hu FB;Willett WC;Cassidy A
目的研究膳食中特定类黄酮亚类（包括黄酮醇、黄酮、黄烷酮、黄烷-3-醇、花青素和类黄酮聚合物）的摄入量是否与体重随时间的变化相关。设计三项前瞻性队列研究。美国的医疗保健专业人员。参与者124086名男性和女性参加了卫生专业人员随访研究（HPFS），护士健康研究（NHS）和护士健康研究II（NHS II）。主要结果测量1986年至2011年期间多个四年时间间隔内自我报告的体重变化。结果：在调整了其他生活方式因素（包括饮食、吸烟状况和体育活动的其他方面）的同时变化后，大多数类黄酮亚类（包括黄酮醇、黄烷-3-醇、花青素和类黄酮聚合物）的摄入量增加与四年时间间隔内的体重变化呈负相关。在汇总的结果中，观察到花青素的关联程度最大（−0.23（95%置信区间−0.30至−0.15）磅/额外标准差/天，10 mg），类黄酮聚合物（-0.18（-0.28至-0.08）磅/额外SD/天，138 mg）和黄酮醇（-0.16（-0.26至-0.06）磅/额外SD/天，7 mg）。在对纤维摄入量进行额外调整后，花青素、原花青素和总黄酮聚合物的相关性仍然显著，但其他子类的相关性减弱，不再具有统计学意义。结论：富含黄酮醇、黄烷-3-醇、花青素和类黄酮聚合物的食物摄入量增加可能有助于成年后体重的维持，并可能有助于改善预防肥胖及其潜在后果的饮食建议。
Objective To examine whether dietary intake of specific flavonoid subclasses (including flavonols, flavones, flavanones, flavan-3-ols, anthocyanins, and flavonoid polymers) is associated with weight change over time. Design Three prospective cohort studies. Setting Health professionals in the United States. Participants 124 086 men and women participating in the Health Professionals Follow-up Study (HPFS), Nurses’ Health Study (NHS), and Nurses’ Health Study II (NHS II). Main outcome measure Self reported change in weight over multiple four year time intervals between 1986 and 2011. Results Increased consumption of most flavonoid subclasses, including flavonols, flavan-3-ols, anthocyanins, and flavonoid polymers, was inversely associated with weight change over four year time intervals, after adjustment for simultaneous changes in other lifestyle factors including other aspects of diet, smoking status, and physical activity. In the pooled results, the greatest magnitude of association was observed for anthocyanins (−0.23 (95% confidence interval −0.30 to −0.15) lbs per additional standard deviation/day, 10 mg), flavonoid polymers (−0.18 (−0.28 to −0.08) lbs per additional SD/day, 138 mg), and flavonols (−0.16 (−0.26 to −0.06) lbs per additional SD/day, 7 mg). After additional adjustment for fiber intake, associations remained significant for anthocyanins, proanthocyanidins, and total flavonoid polymers but were attenuated and no longer statistically significant for other subclasses. Conclusions Higher intake of foods rich in flavonols, flavan-3-ols, anthocyanins, and flavonoid polymers may contribute to weight maintenance in adulthood and may help to refine dietary recommendations for the prevention of obesity and its potential consequences.