HIV subtypes induce distinct profiles of HIV-specific CD8+ T cell responses
HIV subtypes induce distinct profiles of HIV-specific CD8+ T cell responses
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DOI：
10.1089/aid.2007.0183
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发表时间：
2008-02-01
影响因子：
1.5
通讯作者：
Cao, Huyen
中科院分区：
文献类型：
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作者：
Baker, Chris A. R.;McEvers, Kimberly;Cao, Huyen
CD8（+）T细胞在控制HIV感染中起重要作用，HIV特异性CD8（+）应答的质的差异可能决定免疫控制的程度。我们研究了56名HIV感染者，ARV初治的乌干达人，并研究了亚型在调节HIV特异性T细胞反应中的作用。在我们的研究人群中很容易检测到GAG特异性反应。有趣的是，我们发现与A亚型（n = 35）HIV感染相比，D亚型（n = 21）中的GAG特异性细胞溶解（通过CD107表达测量）显著降低。在确定的表位内的序列分析表明亚型特异性的保守模式。我们的结论是，艾滋病毒亚型可能会促进不同的配置文件的T细胞反应和免疫控制。
CD8(+) T cells play an important role in controlling HIV infection and qualitative differences in HIV-specific CD8(+) responses may determine the degree of immune control. We studied 56 HIV-infected, ARV-naive Ugandans and examined the role of subtypes in modulating their HIV-specific T cell responses. Gag-specific responses were readily detectable in our study population. Interestingly, we found significantly decreased Gag-specific cytolysis (as measured by CD107 expression) in subtype D (n = 21) compared to subtype A (n = 35) HIV infection. Sequence analyses within identified epitopes suggest patterns of conservation that are subtype specific. We conclude that HIV subtypes may promote distinct profiles of T cells responses and immune control.