Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidaemia
Metformin and atorvastatin combination further protect the liver in type 2 diabetes with hyperlipidaemia
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DOI：
10.1002/dmrr.1157
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发表时间：
2011-01-01
影响因子：
8
通讯作者：
Seica, R.
中科院分区：
文献类型：
--
作者：
Matafome, P.;Louro, T.;Seica, R.
背景非酒精性脂肪性肝病（NAFLD）和2型糖尿病与血脂异常、炎症和氧化应激有关。然而，NAFLD在2型糖尿病伴胆固醇血症中的病理生理学尚不完全清楚，以及常用的抗糖尿病和降脂药物在改善肝损伤标记物中的效用。在全身和肝脏炎症和氧化应激标记物进行了测试，使用遗传2型糖尿病Goto-Kakizaki大鼠喂高脂diet.Results高脂饮食加重整体代谢状态和肝脏损伤的标志物。所有治疗均降低空腹血糖、胰岛素抵抗和游离脂肪酸水平。联合治疗进一步降低C-反应蛋白（CRP），脂联素，肝肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6），全身和肝脏氧化应激和门静脉inflammation.Conclusions我们的数据提供了证据，阿托伐他汀和二甲双胍的组合，在改善肝损伤2型糖尿病合并糖尿病。版权所有（C）2010约翰威利父子有限公司
Background Non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes are associated with dyslipidaemia, inflammation and oxidative stress. However, the pathophysiology of NAFLD in type 2 diabetes with hyperlipidaemia is not fully known, as well as the utility of the commonly prescribed anti-diabetic and lipid-lowering drugs in ameliorating liver injury markers.Methods Hepatic complications of type 2 diabetes with hyperlipidaemia and the effects of atorvastatin and metformin, isolated and in association, in systemic and hepatic inflammatory and oxidative stress markers were tested using genetic type 2 diabetic Goto-Kakizaki rats fed with a high-fat diet.Results The high-fat diet aggravated the overall metabolic state and the hepatic markers of injury. All treatments decreased fasting glycaemia, insulin resistance and free fatty acid levels. Combined treatment further decreased C-reactive protein (CRP), adiponectin, liver tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), systemic and hepatic oxidative stress and portal inflammation.Conclusions Our data provides evidence of a greater benefit with a combination of atorvastatin and metformin in improving liver injury in type 2 diabetes with hyperlipidaemia. Copyright (C) 2010 John Wiley & Sons, Ltd.