Early-life origin and prevention of chronic obstructive pulmonary diseases
Early-life origin and prevention of chronic obstructive pulmonary diseases
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DOI：
10.1111/pai.13157
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发表时间：
2020-02-01
影响因子：
4.4
通讯作者：
Baraldi, Eugenio
中科院分区：
文献类型：
--
作者：
Moschino, Laura;Carraro, Silvia;Baraldi, Eugenio
慢性阻塞性呼吸系统疾病，如哮喘和慢性阻塞性肺病（COPD）的根源都在子宫里。与遗传易感性一起，产前和早期生活因素，包括母亲吸烟、早产和支气管肺发育不良（BPD），在后来的呼吸系统健康中起着关键作用。因此，对呼吸道病毒（特别是呼吸道合胞病毒和鼻病毒）的不适当反应和早期过敏性致敏是导致喘息和早发性哮喘的最重要因素。迫切需要早期疾病生物标志物来识别慢性呼吸系统疾病高风险人群。在这方面，将“-omic”技术应用于尿液、血液和呼吸冷凝物以及非侵入性炎症测量似乎很有希望。具体风险概况的描述可能是使用有针对性的个性化治疗的关键。
Chronic obstructive respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD) have their roots in the womb. Together with a genetic predisposition, prenatal and early-life factors, including maternal smoking, prematurity, and bronchopulmonary dysplasia (BPD), have a pivotal role in later respiratory health. Then, inappropriate responses to respiratory viruses (especially respiratory syncytial virus and rhinovirus) and early allergic sensitization are the strongest contributors to the inception of wheezing and early-onset asthma. There is an urgent need for early disease biomarkers to identify profiles at higher risk of chronic respiratory conditions. Applying the "-omic" technologies to urine, blood and breath condensate, and non-invasive inflammometry seem promising in this regard. The description of specific risk profiles may be the key to the use of targeted personalized therapies.