Outpatient parenteral antimicrobial therapy (OPAT): is it safe for selected patients to self-administer at home? A retrospective analysis of a large cohort over 13 years
Outpatient parenteral antimicrobial therapy (OPAT): is it safe for selected patients to self-administer at home? A retrospective analysis of a large cohort over 13 years
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DOI：
10.1093/jac/dkm210
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发表时间：
2007-08-01
影响因子：
5.2
通讯作者：
Byren, Ivor
中科院分区：
文献类型：
--
作者：
Matthews, Philippa C.;Conlon, Christopher P.;Byren, Ivor
目的：门诊肠外抗菌治疗 (OPAT) 是一个不断发展的领域，可促进特定严重感染患者的出院。我们报告了一个大型 OPAT 队列，重点关注患者和亲属在社区中监督肠外抗生素给药的实践，我们统称为“自我给药”。为了区分医疗保健专业人员 OPAT 和自行给药的 OPAT，我们分别创造了术语 H-OPAT 和 S-OPAT。 患者和方法：我们分析了 1993 年至 2005 年 13 年期间前瞻性收集的 2059 次 OPAT 发作的数据。结果：该 OPAT 系列中的临床诊断、微生物学和抗生素与之前报道的数据相当。与 H-OPAT 组相比，我们发现 S-OPAT 组没有出现过多的并发症或再次入院。结论：在专家团队的监督下，对选定的患者进行自我静脉注射抗菌治疗是一种安全可行的策略。
Objectives: Provision of outpatient parenteral antimicrobial therapy (OPAT) is an evolving field, facilitating discharge from hospital for selected patients with serious infections. We report on a large OPAT cohort focusing on the practice of supervised parenteral antibiotic administration in the community by patients and relatives, which we collectively term 'self-administration'. To distinguish between healthcare professional OPAT and self-administered OPAT, we have coined the terms H-OPAT and S-OPAT, respectively.Patients and methods: We analysed data on 2059 OPAT episodes collected prospectively over a 13 year time period from 1993 to 2005.Results: Clinical diagnosis., microbiology and antibiotics in this OPAT series are comparable to those previously reported. We identified no excess complications or hospital re-admissions in the S-OPAT group compared with the H-OPAT group.Conclusions: Self-administration of intravenous antimicrobial therapy, in selected patients under the supervision of a specialist team, is a safe and feasible strategy.