EFFECT OF BLOOD-TRANSFUSION ON OXYGEN-CONSUMPTION IN PEDIATRIC SEPTIC SHOCK
EFFECT OF BLOOD-TRANSFUSION ON OXYGEN-CONSUMPTION IN PEDIATRIC SEPTIC SHOCK
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DOI：
10.1097/00003246-199010000-00007
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发表时间：
1990-10-01
影响因子：
8.8
通讯作者：
POLLACK, MM
中科院分区：
文献类型：
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作者：
MINK, RB;POLLACK, MM
儿科败血性休克的治疗计划提倡增加耗氧量（≥ VO2）。最近对败血性休克的研究表明，通过增加血流来改善氧输送（≥ DO2）将增加≥ VO2。我们前瞻性地检查了在8名血流动力学稳定的脓毒性休克患者中通过输血增加氧含量（CO2）来改善DO2对VO2的影响。输注包括8至10 ml/kg的浓缩红细胞，输注时间为1至2 h。血液动力学和氧运输测量前和输血后。输血显著（p <0.05）增加了Hgb和Hct，从10.2 ± 0.05。0.8 g/dl和30. ±. 2%至13.2.+-。1.4 g/dl和39. ±. 4%（平均值±. SD）。在输血后DO2显著地（p <0.05）增加得更高（599 ± 0.05）。65到818.+-. 189 ml/min。m2），但VO2不改变（166. ±. 68至176.+-. 74 ml/min。m2; NS）。在儿科败血性休克患者中，通过输血增加CO2可能不会增加VO2。
Treatment plans for pediatric septic shock advocate increasing oxygen consumption (.ovrhdot.VO2). Recent studies in septic shock indicate that improving oxygen delivery (.ovrhdot.DO2) by increasing blood flow will increase .ovrhdot.VO2. We prospectively examined the effect on .ovrhdot.VO2 of improving .ovrhdot.DO2 by increasing oxygen content (CO2) with blood transfusion in eight hemodynamically stable septic shock patients. Transfusion consisted of 8 to 10 ml/kg of packed RBC over 1 to 2 h. Hemodynamic and oxygen transport measurements were obtained before and after blood transfusion. Transfusion significantly (p < .05) increased Hgb and Hct from 10.2 .+-. 0.8 g/dl and 30 .+-. 2% to 13.2 .+-. 1.4 g/dl and 39 .+-. 4%, respectively (mean .+-. SD). .ovrhdot.DO2 significantly (p < .05) increased higher after transfusion (599 .+-. 65 to 818 .+-. 189 ml/min .cntdot. m2), but .ovrhdot.VO2 did not change (166 .+-. 68 to 176 .+-. 74 ml/min .cntdot. m2; NS). In pediatric septic shock patients, increasing CO2 by blood transfusion may not increase .ovrhdot.VO2.