Lipid transfer protein allergy: primary food allergy or pollen/food syndrome in some cases
Lipid transfer protein allergy: primary food allergy or pollen/food syndrome in some cases
复制标题
脂质转移蛋白过敏：某些情况下是原发性食物过敏或花粉/食物综合症
DOI：
10.1097/aci.0b013e32814a5401
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发表时间：
2007
影响因子：
2.8
通讯作者：
R. van Ree
中科院分区：
文献类型：
--
作者：
L. Zuidmeer;R. van Ree
综述目的总结关于食物过敏中非特异性脂质转移蛋白的最新发现，特别关注致敏的定位、稳定性和途径。最新发现植物非特异性脂质转移蛋白是主要的食物过敏原，特别是在地中海地区。它们已被确定为许多食物中的过敏原，而且这个名单还在不断增加。由于非特异性脂质转移蛋白被认为是“真正的”食物过敏原，可直接通过胃肠道致敏，因此对其在食品加工和胃消化过程中的稳定性进行了更详细的研究。此外，几个小组试图确定脂质转移蛋白反应性患者的致敏模式，以确定并可能澄清观察到的致敏地理差异。已经提出了不同的致敏途径（通过呼吸道甚至经皮）。摘要 随着非特异性脂质转移蛋白的结构和分子特性得到解决，并且更纯化的非特异性脂质转移蛋白可用于诊断目的，对致敏模式和途径的详细研究变得可行。对脂质转移蛋白致敏模式的持续研究将为脂质转移蛋白相关食物过敏的发展和可能的治疗提供更多的见解。
Purpose of review To summarize recent findings on non-specific lipid transfer proteins in food allergy, with a specific focus on the localization, stability and route of sensitization. Recent findings Plant non-specific lipid transfer proteins are major food allergens, especially in the Mediterranean area. They have been identified as allergens in a number of foods and the list grows ever longer. As non-specific lipid transfer proteins are considered to be ‘true’ food allergens that sensitize directly via the gastrointestinal tract their stability during food processing and gastric digestion has been studied in more detail. In addition, several groups have tried to determine the sensitization patterns of lipid transfer protein-reactive patients, to determine and possibly clarify the observed geographical differences in sensitization. Different sensitization routes (via the respiratory tract or even transdermally) have been suggested. Summary As the structure and molecular properties of non-specific lipid transfer proteins are resolved and more purified non-specific lipid transfer proteins become available for diagnostic purposes, detailed studies on the sensitization pattern and route are becoming feasible. Continuing studies on the pattern of lipid transfer protein sensitization will give more insight into the development and possible treatment of lipid transfer protein-related food allergy.