A HUMAN ONCOGENE FORMED BY THE FUSION OF TRUNCATED TROPOMYOSIN AND PROTEIN TYROSINE KINASE SEQUENCES
A HUMAN ONCOGENE FORMED BY THE FUSION OF TRUNCATED TROPOMYOSIN AND PROTEIN TYROSINE KINASE SEQUENCES
复制标题
DOI：
10.1038/319743a0
复制
发表时间：
1986-02-27
期刊：
影响因子：
64.8
通讯作者：
BARBACID, M
中科院分区：
文献类型：
--
作者：
MARTINZANCA, D;HUGHES, SH;BARBACID, M
在人类结肠癌中存在的转化基因的生物活性互补DNA克隆包含原肌球蛋白和以前未知的蛋白酪氨酸激酶的基因序列。该癌基因编码的蛋白质(641个氨基酸)似乎是通过体细胞重排形成的，该重排用非肌肉原肌球蛋白分子的前221个氨基酸取代了假定的跨膜受体的胞外区。
A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement that replaced the extracellular domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle tropomyosin molecule.