Prevalence and severity of coronary artery disease in diabetic patients with aortic valve calcification
Prevalence and severity of coronary artery disease in diabetic patients with aortic valve calcification
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DOI：
10.2143/ac.66.1.2064962
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发表时间：
2011-02-01
影响因子：
1.6
通讯作者：
Ge, Junbo
中科院分区：
文献类型：
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作者：
Chen, Zhang-wei;Qian, Ju-ying;Ge, Junbo
目的 主动脉瓣钙化（AVC）在老年人中很常见，并与心血管死亡率增加相关，而糖尿病是冠状动脉疾病（CAD）的已知危险因素之一。在本研究中，我们旨在评估接受AVC的2型糖尿病患者CAD的患病率和严重程度。方法2007年6月至12月，连续收治325例胸痛或胸闷患者进行冠状动脉造影。 CAD的严重程度通过Gensini评分和狭窄血管的数量来评估。所有患者均接受经胸超声心动图检测AVC。结果与非糖尿病患者(n = 221)相比，2型糖尿病患者(n = 104)的CAD患病率相似(66.5% vs. 72.1%，P = 0.312)。根据是否存在 AVC 进一步分类，无论是否患有糖尿病，AVC 患者的 CAD 患病率、平均 Gensini 评分和狭窄血管数量均较高。卡方分析（单变量）后还表明，糖尿病患者 CAD 的 AVC 比值比 (OR) 高于非糖尿病患者（3.405 比 2.515）。然而，在CAD多变量logistic回归分析中，糖尿病组AVC的OR为3.757（P = 0.03），而在非糖尿病组中没有达到统计学意义（OR = 2.130，P = 0.074）。结论 合并AVC的2型糖尿病患者CAD患病率较高且病情较重。
Objective Aortic valve calcification (AVC) is common in the elderly and associated with increased cardiovascular mortality, while diabetes is one of the confirmed risk factors for coronary artery disease (CAD). In this study, we aimed to evaluate the prevalence and severity of CAD in type-2 diabetic patients with AVC.Methods From June to December in 2007, a total of 325 consecutive patients with chest pain or chest distress were admitted for coronary angiography. The severity of CAD was evaluated by the Gensini score and the number of stenosed vessels. All patients underwent transthoracic echocardiography for detecting AVC.Results Compared with the patients without diabetes (n = 221), the type-2 diabetic patients (n = 104) had a similar prevalence of CAD (66.5% vs. 72.1%, P = 0.312). Further classified by the presence of AVC, patients with AVC had a higher prevalence of CAD, average Gensini score and the number of stenosed vessels, both in the group with and without diabetes. It was also demonstrated that the odds ratio (OR) of AVC for CAD in the diabetic patients was higher than in the non-diabetic ones (3.405 vs 2.515) after chi-square analysis (single-variable). However, at multivariable logistic regression analysis for CAD, the OR of AVC was 3.757 (P = 0.03) in diabetic group, while it did not achieve statistical significance in the non-diabetic group (OR = 2.130, P = 0.074).Conclusions Type-2 diabetic patients with AVC had a higher prevalence of and more severe CAD.