Basolateral amygdala encodes upcoming errors but not response conflict
Basolateral amygdala encodes upcoming errors but not response conflict
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DOI：
10.1111/j.1460-9568.2012.08022.x
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发表时间：
2012-03-01
影响因子：
3.4
通讯作者：
Roesch, Matthew R.
中科院分区：
文献类型：
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作者：
Kashtelyan, Vadim;Tobia, Steven C.;Roesch, Matthew R.
自适应行为依赖于对潜在错误的检测，以便可以纠正正在进行的行为。在这里，我们问是否基底外侧杏仁核（ABL）可能担任这一功能，通过检查活动在大鼠执行的任务中，错误引起的两个行为反应相互对立。这种反应竞争或冲突是通过迫使大鼠在大多数试验中自由选择的方向做出反应而产生的。大鼠在这些不一致的试验类型中速度较慢，准确性较低。我们发现，活动在ABL发射更强烈之前，错误的反应，但没有信号的潜在错误正确执行不一致的试验。这些数据支持ABL在错误发生前处理错误的作用，并表明ABL不参与监测冲突，以便纠正正在进行的行为。
Adaptive behavior depends on the detection of potential errors so that ongoing behavior might be corrected. Here, we ask whether basolateral amygdala (ABL) might serve this function by examining activity in rats performing a task in which errors were induced by pitting two behavioral responses against each other. This response competition or conflict was created by forcing rats to respond away from the direction in which they were freely choosing on the majority of trials. Rats were slower and less accurate on these incongruent trial types. We found that activity in ABL fired more strongly prior to errant responses, but did not signal the potential for errors on correctly performed incongruent trials. These data support a role for ABL in processing errors prior to their occurrence and suggest that ABL is not involved in monitoring conflict so that ongoing behavior might be corrected.