EFFICACY OF LIVE ATTENUATED AND INACTIVATED INFLUENZA VACCINES IN SCHOOLCHILDREN AND THEIR UNVACCINATED CONTACTS IN NOVGOROD, RUSSIA
EFFICACY OF LIVE ATTENUATED AND INACTIVATED INFLUENZA VACCINES IN SCHOOLCHILDREN AND THEIR UNVACCINATED CONTACTS IN NOVGOROD, RUSSIA
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DOI：
10.1093/infdis/168.4.881
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发表时间：
1993-10-01
影响因子：
6.4
通讯作者：
ALEXANDROVA, GI
中科院分区：
文献类型：
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作者：
RUDENKO, LG;SLEPUSHKIN, AN;ALEXANDROVA, GI
俄罗斯诺夫哥罗德7-14岁的儿童在2年内接种了俄罗斯冷适应性或灭活流感活疫苗或安慰剂。学校作为一个整体被随机分配到其中一个准备工作。在第一年，疫苗是二价的，含有A型（H3 N2）和A型（H1N1）成分。在第二年，疫苗也含有B型成分。在第一年，所有分离的病毒都是A型（H3 N2）;在第二年，大约四分之三的分离株是B型，其余的是A型（H1N1）。在这两年中，疫苗保护了接种疫苗的儿童。当存在显著差异时，减毒活疫苗比灭活疫苗更具有保护性。在使用减毒活疫苗的学校，疫苗接种率与工作人员和未接种疫苗儿童的患病率呈负相关，表明疫苗减少了病毒传播。
Children aged 7-14 years in Novgorod, Russia, were given Russian live cold-adapted or inactivated influenza vaccines or placebo over a 2-year period. Schools were randomly assigned as a whole to one of the preparations. In the first year, the vaccines were bivalent, containing types A (H3N2) and A (H1N1) components. In the second year, the vaccines also contained a type B component. In the first year, all viruses isolated were type A (H3N2); in the second, about three-quarters of the isolates were type B and the rest type A (H1N1). During both years, the vaccines protected the vaccinated children. Where significant differences existed, the live attenuated vaccine was more protective than the inactivated. Vaccination rates in schools in which live attenuated vaccines had been used were inversely related to illness rates of staff and unvaccinated children, suggesting that viral transmission had been reduced by the vaccine.