Insulin secretion and sensitivity in space flight: Diabetogenic effects
Insulin secretion and sensitivity in space flight: Diabetogenic effects
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DOI：
10.1016/s0899-9007(02)00940-1
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发表时间：
2002-10-01
期刊：
影响因子：
4.4
通讯作者：
Leeper-Woodford, SK
中科院分区：
文献类型：
--
作者：
Tobin, BW;Uchakin, PN;Leeper-Woodford, SK
近三十年的空间飞行研究表明，在微重力条件下会发生亚临床糖尿病变化。胰岛素分泌、胰岛素敏感性、葡萄糖耐量以及蛋白质和氨基酸代谢的改变支持了这样的假设，即胰岛素在长时间太空飞行中维持肌肉质量方面起着至关重要的作用。飞行中和飞行后的实验以及地面卧床研究将微重力及其实验范式与类似于糖尿病、缺乏体力活动和衰老的表现联系起来。我们认为，这些表现的最佳特征在于病因学，其福尔斯属于糖尿病的“其他”病因的临床类别，包括但不限于遗传性β细胞缺陷、胰岛素作用缺陷、内分泌胰腺疾病、内分泌病、药物或化学诱导的糖尿病、感染、免疫介导的代谢改变和许多遗传相关疾病。我们目前的数据显示，肿瘤坏死因子-α的生产，胰岛素分泌和氨基酸代谢的胰岛细胞培养在地面的细胞培养生物反应器，模仿微重力的影响的一些变化。总之，空间飞行研究，地面研究和胰岛的生物反应器研究支持胰腺在空间飞行期间无法克服外周胰岛素抵抗和氨基酸失调的假设。我们建议，胰岛素分泌和胰岛素作用的措施将是必要的，以设计有效的对策，对肌肉损失，我们提出的“处置指数”作为一个基本模型，用于临床管理空间飞行引起的肌肉损失。(C)Elsevier Science Inc. 2002.
Nearly three decades of space flight research have suggested that there are subclinical diabetogenic changes that occur in microgravity. Alterations in insulin secretion, insulin sensitivity, glucose tolerance, and metabolism of protein and amino acids support the hypothesis that insulin plays an essential role in the maintenance of muscle mass in extended-duration space flight. Experiments in flight and after flight and ground-based bedrest studies have associated microgravity and its experimental paradigms with manifestations similar to those of diabetes, physical inactivity, and aging. We propose that these manifestations are characterized best by an etiology that falls into the clinical category of "other" causes of diabetes, including, but not restricted to, genetic beta-cell defects, insulin action defects, diseases of the endocrine pancreas, endocrinopathies, drug or chemically induced diabetes, infections, immune-mediated metabolic alteration, and a host of genetic related diseases. We present data showing, alterations in tumor necrosis factor-alpha production, insulin secretion, and amino acid metabolism in pancreatic islets of Langerhans cultured in a ground-based cell culture bioreactor that mimics some of the effects of microgravity. Taken together, space flight research, ground-based studies, and bioreactor studies of pancreatic islets of Langerhans support the hypothesis that the pancreas is unable to Overcome peripheral insulin resistance and amino acid dysregulation during space flight. We propose that measures of insulin secretion and insulin action will be necessary to design effective countermeasures against muscle loss, and we advance the "disposition index" as an essential model to be used in the clinical management of space flight-induced muscle loss. (C) Elsevier Science Inc. 2002.