DOES THE HIGHER-ORDER STRUCTURE OF THE INFLUENZA-VIRUS RIBONUCLEOPROTEIN GUIDE SEQUENCE REARRANGEMENTS INFLUENZA VIRAL-RNA
DOES THE HIGHER-ORDER STRUCTURE OF THE INFLUENZA-VIRUS RIBONUCLEOPROTEIN GUIDE SEQUENCE REARRANGEMENTS INFLUENZA VIRAL-RNA
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DOI：
10.1016/0092-8674(83)90394-x
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发表时间：
1983-01-01
期刊：
影响因子：
64.5
通讯作者：
ROBERTSON, JS
中科院分区：
文献类型：
--
作者：
JENNINGS, PA;FINCH, JT;ROBERTSON, JS
Subgenomic RNA (sgRNA) were isolated from defective interfering virus produced by high multiplicity passage of the human influenza strain A/PR/8/34. Cloning and sequencing of 35 unique sgRNA revealed that many were .apprx. 400 nucleotides long, containing .apprx. 200 nucleotides from each of the 5'' and 3'' ends of a full-length segment. Most of the sgRNA were derived from segment 1, but there were examples from 6 other segments, including those encoding the hemagglutinin and neuraminidase. The analysis of the sequence rearrangements found in sgRNA indicates that they may be generated from the standard viral segments by a jumping viral polymerase that makes transitions between adjacent regions of the RNA template in the ribonucleoprotein tertiary structure.
