Biosafety and Biokinetics of Noble Metals: The Impact of Their Chemical Nature
Biosafety and Biokinetics of Noble Metals: The Impact of Their Chemical Nature
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DOI：
10.1021/acsabm.9b00630
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发表时间：
2019-10-21
影响因子：
4.7
通讯作者：
Voliani, Valerio
中科院分区：
文献类型：
--
作者：
Cassano, Domenico;Mapanao, Ana-Katrina;Voliani, Valerio
纳米结构贵金属的有效排泄仍然是其在临床实践中应用的最具挑战性的瓶颈之一。除了持久性问题，无机纳米材料的临床转化也受到缺乏定量生物学研究的影响。在这里，我们已经定量相关的化学性质的三个最有趣的贵金属的生物医学应用，其生物安全性和生物活性，分别为斑马鱼和小鼠模型。金、银和铂的超小纳米结构具有可比的尺寸，静脉给药后，不同的排泄途径取决于其固有的金属性质。了解贵金属纳米颗粒的体内命运是一个重大突破，以解锁其临床应用，建立肿瘤，传染病和神经系统疾病的治疗。
Effective excretion of nanostructured noble metals is still one of the most challenging bottlenecks for their employment in clinical practice. Besides the persistence issue, the clinical translation of inorganic nanomaterials is also affected by a bewildering lack of investigations regarding their quantitative biokinetics. Here, we have quantitatively correlated the chemical nature of the three most interesting noble metals for biomedical applications to their biosafety and biokinetics in, respectively, zebrafish and murine models. Gold, silver, and platinum ultrasmall-in-nano architectures with comparable size elicit, after intravenous administration, different excretion pathways depending on their intrinsic metallic nature. Understanding the in vivo fate of noble metal nanoparticles is a significant breakthrough to unlock their clinical employment for the establishment of treatments for neoplasms, infectious diseases, and neurological disorders.