Lower HDL-C and apolipoprotein A-I are related to higher glomerular filtration rate in subjects without kidney disease
Lower HDL-C and apolipoprotein A-I are related to higher glomerular filtration rate in subjects without kidney disease
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DOI：
10.1194/jlr.m005348
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发表时间：
2010-07-01
影响因子：
6.5
通讯作者：
Dullaart, Robin P. F.
中科院分区：
文献类型：
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作者：
Krikken, Jan A.;Gansevoort, Ron T.;Dullaart, Robin P. F.
动物实验表明，肾脏有助于载脂蛋白(Apo)A-I的分解代谢。我们在没有严重慢性肾脏疾病的受试者中测试了高密度脂蛋白胆固醇(高密度脂蛋白-C)和载脂蛋白I与肾功能的关系。纳入的是普通人群的随机样本(PREVEND队列的一部分)。对2484名空腹受试者(e-GFR=45ml/min/1.73m(2))进行了肾功能、高密度脂蛋白-C、甘油三酯、载脂蛋白A-I和胰岛素抵抗(HOMA(Ir))的测定，这些受试者没有大量白蛋白尿、心血管疾病、糖尿病，也没有使用降压药和/或降脂药物。在单因素分析中，高密度脂蛋白胆固醇(r=-0.056~-0.102，P<；0.01~0.001)和载脂蛋白A-I(r=-0.096~-0.126，P<；0.001)与肾小球滤过率和内生肌酐清除量均呈负相关。多元线性回归分析还显示，即使在调整了年龄、性别、腰围、HOMA(IR)、甘油三酯和尿白蛋白排泄量后，高密度脂蛋白-C和载脂蛋白A-I与肾功能的所有指标也呈负相关(P=0.053-0.004)。结论：在肾功能没有严重受损的受试者中，高密度脂蛋白-C和载脂蛋白A-I与e-GFR和肌酐清除呈负相关，这符合肾脏对载脂蛋白A-I调节的概念。高肾小球滤过率可能是促动脉粥样硬化脂蛋白特征的独立决定因素。-Krikken，J.A.，R.T.Gansevoort和R.P.F Dullaart代表PREVEND研究小组。在无肾脏疾病的受试者中，低密度脂蛋白胆固醇和载脂蛋白A-I与较高的肾小球滤过率有关。J.Lipid Res.2010年。51：1982-1990。
Animal experiments show that the kidney contributes to apolipoprotein (apo) A-I catabolism. We tested relationships of HDL cholesterol (HDL-C) and apo-I with kidney function in subjects without severe chronic kidney disease. Included was a random sample of the general population (part of the PREVEND cohort). Kidney function [estimated glomerular filtration rate (e-GFR) by two well-established equations and creatinine clearance], HDL-C, triglycerides, apoA-I and insulin resistance (HOMA(ir)) were measured in 2,484 fasting subjects (e-GFR >= 45 ml/min/1.73m(2)) without macroalbuminuria, cardiovascular disease, diabetes, or the use of anti-hypertensives and/or lipid-lowering agents. HDL-C (r = -0.056 to -0.102, P < 0.01 to < 0.001) and apo A-I (r = -0.096 to -0.126, P < 0.001) were correlated inversely with both GFR estimates and creatinine clearance in univariate analyses. Multiple linear regression analyses also demonstrated inverse relationships of HDL-C and apoA-I with all measures of kidney function even after adjustment for age, sex, waist circumference, HOMA(ir), triglycerides, and urinary albumin excretion (P = 0.053 to 0.004).jlr In conclusion, HDL-C and apoA-I are inversely related to e-GFR and creatinine clearance in subjects without severely compromised kidney function, which fits the concept that the kidney contributes to apoA-I regulation in humans. High glomerular filtration rate may be an independent determinant of a pro-atherogenic lipoprotein profile.-Krikken, J. A., R. T. Gansevoort, and R. P. F Dullaart on behalf of the PREVEND Study Group. Lower HDL-C and apolipoprotein A-I are related to higher glomerular filtration rate in subjects without kidney disease. J. Lipid Res. 2010. 51: 1982-1990.