Radio-frequency ablation of hepatic metastases: postprocedural assessment with a US microbubble contrast agent--early experience.
Radio-frequency ablation of hepatic metastases: postprocedural assessment with a US microbubble contrast agent--early experience.
复制标题
肝转移的射频消融：使用美国微泡造影剂进行术后评估——早期经验。
DOI：
10.1148/radiology.211.3.r99jn06643
复制
发表时间：
1999
期刊：
影响因子：
19.7
通讯作者：
G. Gazelle
中科院分区：
文献类型：
--
作者：
L. Solbiati;S. Goldberg;T. Ierace;Marina Dellanoce;T. Livraghi;G. Gazelle
目的
目的评价超声造影剂(US)对肝转移瘤射频消融术后未治疗肿瘤的诊断价值。
材料和方法
20例孤立性结直肠癌肝转移患者接受了经皮射频肿瘤消融术。消融前和消融后分别进行平扫和增强彩色及能量多普勒超声和增强螺旋CT扫描。术后24小时复查CT和US。将超声和CT的表现进行比较。
结果
消融前20例转移瘤中15例超声平扫显示瘤内信号。注射造影剂后，这一信号增强。消融后24小时超声造影显示3个肿瘤残留强化灶，而平扫均未见超声信号。CT显示这三个肿瘤和另外三个US未见的小的(<；3 mm)持续性残留强化灶(US敏感性50%；特异性100%；CT诊断符合率85%)。所有6名有肿瘤残留证据的患者都进行了重复射频消融。
结论
对比剂增强超声可以显示射频治疗后残留的肿瘤，从而可以进行额外的定向治疗。治疗疗程和/或辅助成像操作的潜在减少可能会增加经皮消融局灶性肝转移瘤的易用性和实用性。
PURPOSE
To evaluate contrast agent-enhanced ultrasonography (US) in the detection of untreated tumor after radio-frequency (RF) ablation of hepatic metastases.
MATERIALS AND METHODS
Twenty patients with solitary colorectal liver metastases underwent percutaneous RF tumor ablation. Pre- and postablation imaging was performed with nonenhanced and enhanced color and power Doppler US and contrast-enhanced helical computed tomography (CT). Initial follow-up CT and US were performed 24 hours after ablation. The findings at US and CT were compared.
RESULTS
Nonenhanced US demonstrated intratumoral signal in 15 of 20 metastases before ablation. This signal increased after contrast agent administration. Contrast-enhanced US performed 24 hours after ablation demonstrated residual foci of enhancement in three tumors, whereas no US signals were seen in any tumor on nonenhanced scans. CT demonstrated small (< 3-mm) persistent foci of residual enhancement in these three tumors and in three additional lesions that were not seen at US (US sensitivity, 50%; specificity, 100%; diagnostic agreement with CT, 85%). All six patients with evidence of residual tumor underwent repeat RF ablation.
CONCLUSION
Contrast-enhanced US may depict residual tumor after RF application and thereby enable additional directed therapy. The potential reduction in treatment sessions and/or ancillary imaging procedures might increase the ease and practicality of percutaneous ablation of focal hepatic metastases.