Intermolecular coupling of isomerizable alkenes to heterocycles via rhodium-catalyzed C-H bond activation
Intermolecular coupling of isomerizable alkenes to heterocycles via rhodium-catalyzed C-H bond activation
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DOI：
10.1021/ja0281129
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发表时间：
2002-11-27
影响因子：
15
通讯作者：
Ellman, JA
中科院分区：
文献类型：
--
作者：
Tan, KL;Bergman, RG;Ellman, JA
这报告了第一个未活化的烯烃，包括异构化烯烃，使用Rh（I）催化剂的杂环的范围内的分子间偶联。引入了多种官能团，包括酯、腈和缩醛。在发现弱酸显著增加分子间和分子内反应的速率后，分子间偶联成为可能。
This reports first intermolecular coupling of unactivated alkenes, including isomerizable alkenes, to a range of heterocycles using a Rh(I) catalyst. A variety of functional groups were incorporated, including esters, nitriles, and acetals. The intermolecular coupling became possible after it was discovered that weak acids dramatically increase the rate of both the inter- and intramolecular reactions.