The Beneficial Effects of a Polysaccharide from Moringa oleifera Leaf on Gut Microecology in Mice.
The Beneficial Effects of a Polysaccharide from Moringa oleifera Leaf on Gut Microecology in Mice.
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DOI：
10.1089/jmf.2018.4382
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发表时间：
2019-09
影响因子：
2.4
通讯作者：
F. Wang;Yifan Bao;Jianmin Si;Yu Duan;Zebin Weng;Xinchun Shen
中科院分区：
文献类型：
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作者：
F. Wang;Yifan Bao;Jianmin Si;Yu Duan;Zebin Weng;Xinchun Shen
辣木是一种具有很高营养价值和药理价值的天然植物。油橄榄叶含有多种活性物质。在我们之前的研究中，我们从油橄榄叶中分离得到了一种多糖，即MOs-2-a （1.35 × 104 Da）。在本研究中，每天给6周龄ICR小鼠注射这种多糖，持续4周。然后，研究癌症研究所（ICR）小鼠的体重、免疫、肠道消化和肠道微环境。多糖喂养干预4周后，ICR小鼠的器官指数、消化酶、血清肿瘤坏死因子- α和二胺氧化酶水平均显著提高，免疫和肠道消化能力显著提高。多糖可以通过增加已报道的具有抗肥胖作用的细菌、短链脂肪酸的产生和乳酸的产生来调节小鼠肠道的微生物组成。这些结果表明，油橄榄叶多糖可能是一种很有前景的益生元，具有促进健康的作用。
Moringa oleifera is a natural plant with high nutritional and pharmacological value. Leaves of M. oleifera contain a variety of active substances. In our previous research, we had obtained a polysaccharide separated from M. oleifera leaf, namely MOs-2-a (1.35 × 104 Da). In this study, this polysaccharide was administrated daily to 6 week-old ICR mice for 4 weeks. Then, the body weight, immunity, intestinal digestion, and intestinal microenvironment of Institute of Cancer Research (ICR) mice were investigated. After 4 weeks of feeding intervention with the polysaccharide, the immune and intestinal digestive ability of the ICR mice were significant as shown by the organ index, digestive enzymes, and reduction of serum tumor necrosis factor-alpha and diamine oxidase levels. The polysaccharide could regulate the microbial composition of the intestinal tract in mice by increasing the bacteria that have been reported for antiobesity effects, short chain fatty acid production, and lactic acid production. These findings indicate that the polysaccharide of M. oleifera leaf might be a promising prebiotic that exhibits health promotion effects.