Effects of enteral nutrition supplemented with glutamine on intestinal mucosal immunity in burned mice
Effects of enteral nutrition supplemented with glutamine on intestinal mucosal immunity in burned mice
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DOI：
10.1016/j.nut.2008.08.009
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发表时间：
2009-02-01
期刊：
影响因子：
4.4
通讯作者：
Ma, Liang
中科院分区：
文献类型：
--
作者：
Fan, Jun;Meng, Qingyan;Ma, Liang
Objective: The aim of this study was to investigate the effects of enteral nutrition (EN) supplemented with glutamine (GLN) on Peyer's patches and intestinal immunoglobulin A (IgA) response in burned mice.Methods: Thirty-four mice were randomly assigned to a normal control group (n = 40), an EN group (n = 12), and an EN supplemented with GLN (EN + GLN) group (n = 12) and mice in the EN and EN + GLN groups received a 20% total body surface area, full-thickness scald burn on the back. Then the burned mice were fed with conventional EN or EN + GLN for 7 d. There was isonitrogenous and isocaloric intake in the EN and EN + GLN groups. On day 7 after injury, entire intestines were collected and intestinal IgA levels, total lymphocyte yield, lymphocyte subpopulations, and total apoptotic ratio in Peyer's patches were analyzed.Results: Total lymphocyte yield, numbers of lymphocyte subpopulations, and intestinal IgA levels in the EN + GLN group were significantly higher than those in the EN group (P < 0.05). The total apoptotic ratio in Peyer's patches was markedly decreased in the EN + GLN group compared with that in the EN group (P < 0.05).Conclusion: The results indicated that EN supplemented with GLN is superior to conventional EN with respect to improvement of intestinal immunity in burned mice. (C) 2009 Published by Elsevier Inc.
