BIOLOGICAL PROPERTIES OF HIV ISOLATES IN PRIMARY HIV-INFECTION - CONSEQUENCES FOR THE SUBSEQUENT COURSE OF INFECTION
BIOLOGICAL PROPERTIES OF HIV ISOLATES IN PRIMARY HIV-INFECTION - CONSEQUENCES FOR THE SUBSEQUENT COURSE OF INFECTION
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DOI：
10.1097/00002030-199308000-00002
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发表时间：
1993-08-01
期刊：
影响因子：
3.8
通讯作者：
GERSTOFT, J
中科院分区：
文献类型：
--
作者：
NIELSEN, C;PEDERSEN, C;GERSTOFT, J
目的：了解初次感染时分离到的HIV分离株的生物学特性，并将其与随后的感染过程相关联。方法：对17个HIV血清转换者获得的49株HIV分离株进行合胞体诱导能力、对细胞系(MT4和H9)的趋向性和复制率的测定。在17名患者中，有13名患者有症状的原发艾滋病毒感染。结果：从初次感染时采集的第一份标本中分离到6株SI，10例仅检出非SI(NSI)株，1例分离培养为阴性。对于最初分离出SI病毒的所有患者，这种表型在随访期内(范围为17-219周)持续存在。SI分离株患者初次感染期间的发热持续时间长于NSI分离株患者(P=0.05)。两种类型的分离株在随访期间都与CD4淋巴细胞的显著下降有关(P<；0.05)。具有SI分离株的患者发生HIV相关免疫缺陷的速度比具有NSI分离株的患者更快(P<；0.05)。结论：在血清转换期间分离的HIV毒株的生物学表型可能是随后感染过程的重要决定因素。
Objective: To characterize the biological properties of HIV isolates obtained at the time of primary infection, and relate this to the subsequent course of the infection.Methods: Syncytium-inducing (SI) capacity, tropism for cell lines (MT4 and H9) and replication rate were determined in 49 HIV isolates obtained from 17 HIV seroconverters. Thirteen of the 17 patients had a symptomatic primary HIV infection. Correlation between biological phenotype and clinical progression was analysed.Results: SI isolates were recovered in six patients from the first sample taken during primary infection, non-SI (NSI) isolates only were identified in 10 of the patients and isolation culture was negative in one patient. For all patients from whom SI virus was initially isolated, this phenotype persisted during the follow-up period (range, 17-219 weeks). The duration of fever during primary infection was longer for patients with SI isolates than for patients with NSI isolates (P = 0.05). Both types of isolates were associated with a significant fall in CD4 lymphocytes during follow-up (P < 0.05). Patients with SI isolates developed HIV-related immune deficiency more rapidly than patients with NSI isolates (P < 0.05).Conclusions: The biological phenotype of HIV strains isolated during the time of seroconversion may be an important determinant of the subsequent course of the infection.