Multimodal metabolic imaging of cerebral gliomas:: positron emission tomography with [18F] fluoroethyl-L-tyrosine and magnetic resonance spectroscopy
Multimodal metabolic imaging of cerebral gliomas:: positron emission tomography with [18F] fluoroethyl-L-tyrosine and magnetic resonance spectroscopy
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DOI：
10.3171/jns.2005.102.2.0318
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发表时间：
2005-02-01
影响因子：
4.1
通讯作者：
Sabel, M
中科院分区：
文献类型：
--
作者：
Floeth, FW;Pauleit, D;Sabel, M
物体。本研究旨在探讨[F-18]氟乙基-L酪氨酸(FET)正电子发射断层扫描(PET)和磁共振波谱(MR)对可疑胶质瘤患者肿瘤诊断的预测价值。对连续50例新诊断为弥漫性脑胶质瘤的患者进行了FET-PET和磁共振波谱分析，并进行了增强磁共振成像。病灶/脑内FET摄取比值大于1.6被认为是阳性，即肿瘤的迹象。当N-乙酰天冬氨酸(NAA)降低，胆碱(CHO)绝对值增加，NAA/CHO比值小于或等于0.7时，MR波谱结果为阳性。将FET病变/脑比值、NAA/Cho比值和MR图像上的信号异常与神经导航活检标本的组织学结果进行比较。在MR成像上认为是弥漫性胶质瘤的脑内病变患者中，FET-PET和MR光谱分析显著提高了靶向活检的诊断效率。
Object. The purpose of this study was to determine the predictive value of [F-18]fluoroethyl-L-tyrosine (FET)-positron emission tomography (PET) and magnetic resonance (MR) spectroscopy for tumor diagnosis in patients with suspected gliomas.Methods. Both FET-PET and MR spectroscopy analyses were performed in 50 consecutive patients with newly diagnosed intracerebral lesions supposed to be diffuse gliomas on contrast-enhanced MR imaging. Lesion/brain ratios of FET uptake greater than 1.6 were considered positive, that is, indicative of tumor. Results of MR spectroscopy were considered positive when N-acetylaspartate (NAA) was decreased in conjunction with an absolute increase of choline (Cho) and an NAA/Cho ratio of 0.7 or less. An FET lesion/brain ratio, an NAA/Cho ratio, and signal abnormalities on MR images were compared with histological findings in neuronavigated biopsy specimens.Conclusions. In patients with intracerebral lesions supposed to be diffuse gliomas on MR imaging, FET-PET and MR spectroscopy analyses markedly improved the diagnostic efficacy of targeted biopsies.