Vaccination against SIV infection and disease.
Vaccination against SIV infection and disease.
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针对 SIV 感染和疾病的疫苗接种。
DOI：
10.1089/aid.1990.6.835
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发表时间：
1990
影响因子：
1.5
通讯作者：
Gardner,MB
中科院分区：
文献类型：
--
作者：
Gardner,MB
(SIV)提供了与获得性免疫缺陷综合征（AIDS）非常相似的动物模型，并且非常适合于研究人免疫缺陷病毒（HIV）疫苗策略（Desrosiers和Letvin：Rev Infect Dis 1987; 9：438-446;丹尼尔和Desrosiers：AIDS 1989; 3：S31-33; Gardner和Luciw FASEB J 1989; 3：2593-2606）。这篇小综述总结了来自三个美国灵长类动物中心的最新结果：新英格兰、三角洲和加州，在这些中心，SIV模型已被用于HIV疫苗的开发。值得注意的是，这些中心中的每一个最近都成功地使用灭活的全病毒疫苗来保护恒河猴免受SIV攻击感染和猿猴AIDS（SAIDS）的发展。这些结果比一年前更为乐观，并为最终研制出艾滋病疫苗带来了一线希望（巴恩斯：J NIH Res 1989; 1：81-88）。
(SIV) provide an animal model very similar to acquired immunodeficiency syndrome (AIDS) and highly suitable for studying human immunodeficiency virus (HIV) vaccine strategies (Desrosiers and Letvin: Rev Infect Dis 1987; 9: 438-446; Daniel and Desrosiers: AIDS 1989; 3: S31-33; Gardner and Luciw FASEB J 1989; 3: 2593-2606). This minireview summarizes recent results from three US primate centers: New England, Delta, and California, where the SIV model has been used for HIV vaccine development. Remarkably, each of these centers has recently experienced success using inactivated whole virus vaccines to protect rhesus macaques against SIV challenge infection and development of simian AIDS (SAIDS). These results set a more optimistic tone than was present a year ago, and present a glimmer of hope than an AIDS vaccine can eventually be developed (Barnes: J NIH Res 1989; 1: 81-88).