POSTERIOR PATTERN-FORMATION IN C-ELEGANS INVOLVES POSITION-SPECIFIC EXPRESSION OF A GENE CONTAINING A HOMEOBOX
POSTERIOR PATTERN-FORMATION IN C-ELEGANS INVOLVES POSITION-SPECIFIC EXPRESSION OF A GENE CONTAINING A HOMEOBOX
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DOI：
10.1016/0092-8674(88)90131-6
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发表时间：
1988-12-02
期刊：
影响因子：
64.5
通讯作者：
KENYON, C
中科院分区：
文献类型：
--
作者：
COSTA, M;WEIR, M;KENYON, C
在秀丽隐杆线虫的胚胎后发育过程中，后特异性模式的形成需要mab-5基因。在后体区域，mab-5活性控制表皮、神经元和中胚层细胞的分化，以及细胞迁移的方向。在这里，我们发现mab-5RNA定位于后体区域，这表明mab-5活性至少部分是通过在mab-5RNA合成或稳定水平上运作的机制靶向后细胞的。我们还发现mab-5含有一个类似果蝇触角基因的同源盒。这表明，mab-5通过调节基因表达影响细胞分化和细胞迁移，并清楚地表明，在果蝇以外的生物体中，含有homebox的基因影响模式形成的全局方面。
During postembryonic development in C. elegans, posterior-specific pattern formation requires the gene mab-5. Within the posterior body region, mab-5 activity controls epidermal, neuronal, and mesodermal cell differentiation, and also the direction of cell migration. Here, we show that mab-5 RNA is localized in the posterior body region, indicating that mab-5 activity is targeted to posterior cells, at least in part, by a mechanism that operates at the level of mab-5RNA synthesis or stabilization. We also show that mab-5 contains a homeobox similar to that of the Drosophila Antennapedia gene. This suggests that mab-5 influences cell differentiation and cell migration by regulating gene expression, and clearly demonstrates that genes containing homeboxes influence global aspects of pattern formation in organism other than Drosophila.